Mapping short-term brain changes in cannabis users

Not Applicable

Completed

• Conditions: Moderate-to-severe Cannabis Use Disorder (CUD), as defined by the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5); Mental and Behavioural Disorders; Mental and behavioural disorders due to use of cannabinoids

• Registration Number: ISRCTN76056942
• Lead Sponsor: Australian Catholic University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2020-05-12
• Study Completion: 2022-09-30
• Last Update Posted: 27 February 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 116

Inclusion Criteria

Inclusion criteria for all participants:
1. Aged 18 to 55 years
2. Normal-to-corrected vision
3. Fluent in English
4. Meeting safety criteria for MRI scan

Inclusion criteria for cannabis users:
1. Daily/almost daily (>3 days per week) cannabis use for >12 months
2. CUD 4+ DSM-5 symptoms
3. Tried to quit/reduce cannabis use at least once within the past 24 months

Exclusion Criteria

Exclusion criteria for all participants:
1. Any illicit substance and alcohol use for 12 hours before assessment (confirmed by self- report)
2. Currently using prescription medication that affect the central nervous system
3. Current or past diagnosed psychiatric disorders
4. Any current severe psychiatric diagnosis, excepting diagnoses of depression or anxiety
5. History of any neurological disorders
6. History of acquired or traumatic brain injury
7. Currently pregnant
8. Suicidality

Exclusion criteria for cannabis users:
1. Significant use or dependence on alcohol and any illicit substances other than cannabis
2. Illicit drug use past 4 weeks (other than cannabis)

Exclusion criteria for non-cannabis using controls:
1. Significant use or dependence on alcohol and any illicit substances
2. Illicit drug use past 4 weeks

Study & Design

• Study Type: Interventional
• Study Design: Not specified