Cerebellar Alterations in Individuals With a Cannabis Use Disorder

Not Applicable

Completed

• Conditions: Cannabis
• Interventions: Behavioral: Visuo-motor rotation; Behavioral: Explicit strategy

• Registration Number: NCT02816034
• Lead Sponsor: Universitat Pompeu Fabra

Brief Summary

The purpose of this study is to investigate if individuals with a cannabis use disorder have an impaired cerebellar function by assessing possible alterations to their implicit adaptation during a visuomotor rotation task.

Detailed Description

Not available

Study Timeline

• Study Start: 2016-06
• Study First Submitted: 2016-06-06
• Study First Submitted QC: 2016-06-27
• Study First Posted: 2016-06-28
• Primary Completion: 2017-04
• Study Completion: 2017-04
• Status Verified: 2018-11
• Last Update Submitted: 2018-11-01
• Last Update Posted: 2018-11-05

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 32

Inclusion Criteria

• Patients diagnosed with a Cannabis use disorder following Diagnostic and Statistical Manual (DSM-V) criteria.
• Patients screen positive to cannabis in the urine analysis performed a week prior to assessment.
• Right-handed patients.
• Patients provide a signed consent.

Exclusion Criteria

• Patients with another current substance use disorder (with the exception of tobacco).
• Patients with a visual impairment that has not been corrected.
• Patients with a cognitive impairment such as mental retardation.
• Patients with psychotic disorders.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Experimental Explicit	Explicit strategy	Cannabis user performs visuo-motor rotation tasks informed of an explicit strategy to maximise performance
Control Explicit	Visuo-motor rotation	Healthy subject performs visuo-motor rotation tasks informed of an explicit strategy to maximise performance
Control Implicit	Visuo-motor rotation	Healthy subject performs visuo-motor rotation tasks without being informed of the explicit strategy
Experimental Explicit	Visuo-motor rotation	Cannabis user performs visuo-motor rotation tasks informed of an explicit strategy to maximise performance
Experimental Implicit	Visuo-motor rotation	Cannabis user performs visuo-motor rotation tasks without being informed of the explicit strategy
Experimental Implicit	Explicit strategy	Cannabis user performs visuo-motor rotation tasks without being informed of the explicit strategy

Primary Outcome Measures

Name	Time	Method
Directional error of hand trajectories towards a target	1 day (a single session)

Secondary Outcome Measures

Name	Time	Method
Intrinsic Motivational Inventory	1 day (a single session)
Reaction times	1 day (a single session)