Influence of the dietary history in the prevention of coeliac disease: possibilities of induction of tolerance for gluten in genetic predisposed children.

Completed

• Conditions: coeliac disease (coeliakie); gluten; prevention (prevensie); breastfeeding (borstvoeding); early feeding (baby voeding); genetic predisposition (genetisch predispositie); HLA; food intervention (voedings interventie); prospective (prospectief); double blind

• Registration Number: NL-OMON27354
• Lead Sponsor: -

Brief Summary

Statistical Analysis Plan, 74582487, August 1st, 2013, Prof.dr.H. Putter, Dr. M. L. Mearin, Sabine Vriezinga<br> http://preventcd.com/images/stories/Publications/PreventCD_SAP_1_0.pdf

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 28 February 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 1000

Inclusion Criteria

1.Infant born during the study with a first degree relative (parent or sibling) with CD;
2.Informed consent for the study.

Exclusion Criteria

1. No informed consent;
2. Parents-guardians unable to understand the information necessary to give informed consent.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
A reduction of 50% of CD among the intervention group at the age of 3 years will be considered as an effective prevention.<br>

Secondary Outcome Measures

Name	Time	Method
If the proposed early dietary intervention results in effective prevention of CD: <br>1. Development of new European guidelines for early nutrition in order to prevent the disease;<br>2. Identification of the influence of early feeding on the development of coeliac disease in relation with immunological and genetical factors.<br><br><br>