Influence of the dietary history in the prevention of coeliac disease : possibilities of induction of tolerance for gluten in genetically predisposed children. The dutch food intervention study
Completed
- Conditions
- gluten enteropathygluten intolerance10025477
- Registration Number
- NL-OMON30313
- Lead Sponsor
- eids Universitair Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 150
Inclusion Criteria
1. Infant born during the study with a first degree relative (parent or sibling) with Coeliac Disease.
2. Family know by the NCV (Dutch coeliac disease association)
3. Informed consent for the study
Exclusion Criteria
1. No informed consent for the study
2. Insufficient knowledge of the Dutch language. Parents-guardians unable to understand the information necessary to give informed consent
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>In the European project (1000 children), reduction of 50% of CD development in<br /><br>the intervention group at the age of 3 years (25 children with CD, expected<br /><br>50). </p><br>
- Secondary Outcome Measures
Name Time Method <p>- Understanding of the influence of early nutrition on the development of CD in<br /><br>relation to immunologic and genetic factors.<br /><br>- If our strategy to develop tolerance for gluten happens to be effective:<br /><br>contribution to the development of new (evidence based) European guidelines for<br /><br>early infant feeding practices, aimed at the primary prevention of CD and<br /><br>related autoimmune diseases. </p><br>