Generation and phenotypic evaluation of chronotyped iPS cell-derived human SCN organoids

Phase 1

Recruiting

• Conditions: Healthy subjects; D064368

• Registration Number: JPRN-jRCT1030230322
• Lead Sponsor: Kitamura Shingo

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2023-09-04
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 8

Inclusion Criteria

1) Persons who are between 20 and 35 years of age at the time of obtaining consent.

Exclusion Criteria

1) Those with difficulty in blood collection due to alcohol allergy or vasovagal reflex, etc.
2) Patients with pre-existing medical conditions (cardiovascular, liver, endocrine, brain/neurological, psychiatric, etc.), taking therapeutic drugs, or having a history of such conditions that may affect the results of the study
3) Persons who are dependent on alcohol or who are found to be in the habit of excessive alcohol consumption
4) Those who have a habit of taking drugs or supplements that affect sleep
5) Those who have engaged in time-lagged travel or shift work at least six months prior to the experiment.
6) Any other person who is deemed inappropriate by the principal investigator.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
(1) To examine whether the circadian rhythmicity and cycle length observed in the luminescence peak of clock gene expression of SCN organoids reflect individual chronotypic characteristics.<br>(2) To examine whether the circadian rhythmicity and cycle length observed in the luminescence peak of clock gene expression of SCN organoids reflect individual sleep habits.