NCT03742869Unknown不适用
A Multi-omics Study on the Human Papillomavirus Integration and Tumorigenesis of Uterine Cervical Adenocarcinoma
Lei Li1 个研究点 分布在 1 个国家目标入组 40 人开始时间: 2018年11月10日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Frequencies of somatic driving mutations
研究概览
简要总结
This study aims to analyze the multi-omics results between uterine cervical adenocarcinoma patients with and without human papillomavirus (HPV) infections. The multi-omics profiles include genome wide association study (GWAS), whole exome sequencing, analysis of transcriptomics and metabolomics. The HPV integration status is interpreted by GWAS. A comprehensive multi-omics will reveal the role of HPV integration in the molecular mechanism of tumorigenesis and prognosis of uterine cervical adenocarcinoma.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Confirmed primary adenocarcinoma of the uterine cervix
- •Signed an approved informed consents
- •Feasible for biopsy
排除标准
- •Not meeting all of the inclusion criteria
结局指标
主要结局
Frequencies of somatic driving mutations
时间窗: Two years
The differences of frequencies of somatic driving mutations will be compared between patients with and without HPV integration.
次要结局
- Frequencies of alteration of RNA expression(Two years)
- Progression-free survival(Five years)
- Frequencies of alteration of protein expression and signal pathway(Two years)
研究者
Lei Li
Professor
Peking Union Medical College Hospital
研究点 (1)
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