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Clinical Trials/NCT00793637
NCT00793637
Completed
Not Applicable

Prospective Multicenter Case Series to Evaluate Handling and Possible Complications Related to the Angular Stable Locking System in Patients With Proximal and Distal Tibial, Femoral and Humeral Fractures Treated With Intramedullary Nails

AO Clinical Investigation and Publishing Documentation4 sites in 2 countries30 target enrollmentAugust 2008

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Humerus Fracture
Sponsor
AO Clinical Investigation and Publishing Documentation
Enrollment
30
Locations
4
Primary Endpoint
Surgeon's compliance and handling-oriented questionnaire
Status
Completed
Last Updated
4 years ago

Overview

Brief Summary

In many cases, the existing locking bolts and screws in intramedullary nails do not provide sufficient stability. Due to the play between screw and nail, the reduction can be lost and the instability can result in malunions, nonunions, or pseudoarthrosis. Consequently, secondary angular fracture dislocation (defined as a difference of the angle of 10° or more from the post-operative to the follow-up x-rays) can be observed in approximately 30% of patients after conventional intramedullary nailing of proximal third tibial fractures and in approximately 0-2% in patients with distal third tibial fractures. Therefore, an Angular Stable Locking System for Intramedullary Nails (ASLS) was developed to reduce the risk of secondary loss of reduction by providing axial and angular stability. ASLS provides angular stable fixation between nails and screws with resorbable sleeves used as dowels in the nail locking holes.

The present study evaluates the handling of ASLS and the surgeon's compliance as well as any complications occurring during the baseline and the follow-up period in patients with proximal and distal tibial, femoral and humeral fractures treated with intramedullary nails. Furthermore, the relationship of any occurred complications to ASLS will be assessed.

Registry
clinicaltrials.gov
Start Date
August 2008
End Date
August 2009
Last Updated
4 years ago
Study Type
Observational
Sex
All

Investigators

Sponsor
AO Clinical Investigation and Publishing Documentation
Responsible Party
Sponsor

Eligibility Criteria

Inclusion Criteria

  • The patient is ≥ 18 years old
  • One of the following bones is fractured so that the fracture is affecting the proximal or the distal third of the bone without affecting the joint surface: Humerus, Femur, Tibia
  • The fracture is fixed with one of the following cannulated implants Humerus: Expert HN, Expert PHN. Femur: Expert LFN, Expert RAFN, CFN, DFN, AFN. Tibia: Expert TN, CTN.
  • The patient is willing and able to participate in the study follow-up according to the CIP.
  • The patient is able to understand and read local language at elementary level.
  • The patient is willing and able to give written informed consent to participate in the study.
  • Exclusion criteria:
  • The patient is legally incompetent.
  • Preexistent malunion or nonunion of the bone that is planned to be treated with ASLS.
  • The patient suffers from a polytrauma (multiple injuries, whereof one or the combination of several injuries is life-threatening).

Exclusion Criteria

  • Not provided

Outcomes

Primary Outcomes

Surgeon's compliance and handling-oriented questionnaire

Time Frame: During surgery

Secondary Outcomes

  • Rate of Complications(6 months)
  • General pain and pain at fracture site assessed by VAS(6 months)
  • Walking ability in patients with femoral or tibial fractures using the Parker mobility score(6 months)

Study Sites (4)

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