Comparison of 2 drugs for reducing hemodynamic response during Intubation
- Registration Number
- CTRI/2025/04/085152
- Lead Sponsor
- Sardar Patel Medical College Bikaner Rajasthan
- Brief Summary
Laryngoscopy and Intubation are a crucial part of general anaesthesia in a patient undergoing surgery. Sympathetic stimulation and catecholamine release while performing Laryngoscopy and Intubation leads to hemodynamic changes ,mainly Tachycardia and Hypertension.
Many agents are in use for reducing these hemodynamic changes. We plan to use Dexmedetomidine and Magnesium Sulphate in nebulised form, in 90 patients, ASA grade 1 and 2 undergoing elective surgery who need Endotracheal Intubation.
Our aim will be to compare the hemodynamic changes of these two drugs during Laryngoscopy and Intubation. We will also observe the side effects and complications if any.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Not Yet Recruiting
- Sex
- All
- Target Recruitment
- 90
ASA Grade 1 and 2, Age 18-35 years, BMI less than 30, Mallampati grading 1 and 2, Patients undergoing elective surgeries requiring General Anaesthesia with Endotracheal Intubation.
Not provided
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To compare the hemodynamic effects of Nebulised Dexmedetomidine and Nebulised Magnesium Sulphate on the patient during Laryngoscopy and Intubation. Before nebulisation, After nebulisation. | 2, 5, and 10 minutes following Intubation
- Secondary Outcome Measures
Name Time Method To observe any side effects and complications related to the drugs. Intraoperative, Up to 24 hours Post-operatively.
Trial Locations
- Locations (1)
Sardar Patel Medical College, Bikaner, Rajasthan
🇮🇳Bikaner, RAJASTHAN, India
Sardar Patel Medical College, Bikaner, Rajasthan🇮🇳Bikaner, RAJASTHAN, IndiaDr Asif PPrincipal investigator7025862867drasifmuhammedp@gmail.com