Study on the Effectiveness of "Treatment Regulation Mode" Based on Neuromodulation and Electronic Follow-up to Reduce Relapse Behavior in Patients With Substance Dependence
试验速览
- 阶段
- 不适用
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Change from Baseline cue-induced craving at 2 weeks
研究概览
简要总结
Transcranial direct current stimulation (tDCS) combined with computerized cognitive addiction therapy(CCAT) for methamphetamine(MA) dependent patients in voluntary drug rehabilitation center. Electronic medical systems were applied for drug related knowledge education, self-evaluation and outpatient follow-up reminder after intervention in order to reduce relapse behaviors.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Methamphetamine dependent patients with normal eyesight and hearing.
排除标准
- •any diagnosis of DSM-IV axis I diseases.
- •any physical diseases which might influence cognitive function such as epilepsy, cerebrovascular disease or brain injury.
- •negative behaviors or harm to others.
- •cognitive enhance drug use history in last 6 months.
- •other drug dependence(except nicotine).
结局指标
主要结局
Change from Baseline cue-induced craving at 2 weeks
时间窗: 2 weeks
Participants were instructed to watch methamphetamine-related videos by VR and rate their level of craving after smelling and recalling the last time they engaged in drug use. Craving was assessed by visual analog scales (VAS), with 0 mm being "no craving"and 100 mm representing "most craving ever experienced for methamphetamine".
Change from Baseline cue-induced craving at 4 weeks
时间窗: 4 weeks
Participants were instructed to watch methamphetamine-related videos by VR and rate their level of craving after smelling and recalling the last time they engaged in drug use. Craving was assessed by visual analog scales (VAS), with 0 mm being "no craving"and 100 mm representing "most craving ever experienced for methamphetamine".
次要结局
- response inhibition function(2 weeks，4 weeks)
- cognitive function(2 weeks，4 weeks)
- Attention bias towards methamphetamine(2 weeks，4 weeks)
- reward-related function(2 weeks，4 weeks)