The Prevalence and Associated Factors of Early Neurological Deterioration After Successful Recanalization Treatment in Patients With Acute Ischemic Stroke
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Acute Stroke
- Sponsor
- Assiut University
- Enrollment
- 30
- Primary Endpoint
- Prevalence of early neurological deterioration after successful recanalization treatment in patients with acute ischemic stroke
- Last Updated
- 4 years ago
Overview
Brief Summary
stroke is a leading cause of morbidity and mortality worldwide. More than half (54.5%) of the 56.9 million deaths worldwide in 2106 were due to the top 10 causes.
Ischemic heart disease and stroke are the world's biggest killers, accounting for a combined 15.2 million deaths in 2106. These diseases have remained the leading causes of death globally in the last 15 years.
Recent clinical trials have shown that endo-vascular thrombectomy is an effective and safe recanalization modality for acute ischemic stroke patients .
Meta-analysis results show that endovascular treatment is associated with a high ratio of successful recanalization rate and a low rate of symptomatic hemorrhage .
Approximately 2.2-37.5% of patients with acute ischemic stroke might encounter early neurological deterioration (END).
Definition of END: An increase in NIHSS ≥4 or an increase in Ia of NIHSS ≥1 within 72 h after recanalization treatment.
Investigators
Osama Ibrahim Aboelfath Ibrahim
osama ibrahim abo-elfath
Assiut University
Eligibility Criteria
Inclusion Criteria
- •Ischemic stroke of both sex.
- •More than 08 years.
- •Accepting all study requirements.
- •within time window for thrombolysis or thrombectomy
- •fulfilling criteria for thrombolysis or thrombectomy
Exclusion Criteria
- •(A)Absolute Contraindications :
- •Intracerebral hemorrhage history or presence on imaging
- •Time of onset more than 465 hours
- •Blood pressure greater than 085/000 mm Hg
- •Recent severe head trauma or neurosurgical intervention
- •Coagulopathy (INR \>067, thrombocytopenia, recent use of heparin or direct oral anticoagulants)
- •Endocarditis (infective)
- •Aortic dissection (B)Potential Contraindications :
- •1.Seizure at onset 2.Noncompressible arterial puncture 3.Recent surgery 4.Gastrointestinal or genitourinary bleeding 5.Multiple cortical microbleeds (\>00)
- •Large intracranial aneurysms or arteriovenous malformations 7.Recent transmural myocardial infarction
Outcomes
Primary Outcomes
Prevalence of early neurological deterioration after successful recanalization treatment in patients with acute ischemic stroke
Time Frame: 1 year
Prevalence of early neurological deterioration after successful recanalization treatment in patients with acute ischemic stroke
factors of deterioration
Time Frame: 1 year
factors of deterioration