The effects of anesthetics on intracranial pressure: Additional analysis

Not Applicable

• Conditions: Healthy adult volunteers (opt-out) Target population; Patients undergoing sedation or general anesthesia

• Registration Number: JPRN-UMIN000050016
• Lead Sponsor: ihon University

Brief Summary

The present study is a follow-up on our earlier research series, and is based on reanalysis of the data obtained from the previous research series. Participants were given the opportunity to decline consent using an opt-out method; none of the participants requested withdrawal from the study. To estimate ICP during sedation, we analyzed the data from 42 healthy male volunteers whose waveforms were available for calculation of nICP in the previous research series.

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2023-01-12
• Last Update Posted: 17 October 2023
• Study Completion: 2025-03-31

Recruitment & Eligibility

• Status: Complete: follow-up continuing
• Sex: Male
• Target Recruitment: 42

Inclusion Criteria

Not provided

Exclusion Criteria

Participants who desire withdraw from the present study via opt-out.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The changes of Noninvasive ICP (nICP) during sedation or anesthesia

Secondary Outcome Measures

Name	Time	Method
Cerebral blood flow (CBF), arterial blood pressure, cerebrovascular resistance, CBF pulsatility index (PI), etc.