Carotid Ultrasound in the Evaluation of Heart Failure

Not Applicable

Completed

• Conditions: Heart Failure; Coronary Artery Disease; Cardiomyopathy
• Interventions: Other: Carotid ultrasound

• Registration Number: NCT00810550
• Lead Sponsor: NYU Langone Health

Brief Summary

Coronary artery disease (CAD, cholesterol plaque buildup in the heart arteries) is the most common cause of left ventricular systolic dysfunction (weakening of the heart muscle). The standard test to find coronary artery disease is coronary angiography. This test is highly accurate but is invasive and carries a small risk of complications. This study investigates ultrasound of the carotid (neck) arteries as a screening test for severe coronary artery disease as a cause of left ventricular systolic dysfunction. It is hypothesized that carotid ultrasound will have excellent negative predictive value for severe CAD.

Detailed Description

Coronary artery disease (CAD, cholesterol plaque buildup in the heart arteries) is the most common cause of left ventricular systolic dysfunction (weakening of the heart muscle). The standard test to find coronary artery disease is coronary angiography. This test is highly accurate but is invasive and carries a small risk of complications. This study investigates ultrasound of the carotid (neck) arteries as a screening test for severe coronary artery disease as a cause of left ventricular systolic dysfunction. It is hypothesized that carotid ultrasound will have excellent negative predictive value for severe CAD.

Study Timeline

• Study Start: 2005-10
• Primary Completion: 2008-12
• Study Completion: 2008-12
• Study First Submitted: 2008-12-17
• Study First Submitted QC: 2008-12-17
• Study First Posted: 2008-12-18
• Status Verified: 2016-04
• Last Update Submitted: 2016-04-05
• Last Update Posted: 2016-04-06

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 150

Inclusion Criteria

• LVEF 40% or less

Exclusion Criteria

• Prior diagnosis of coronary or carotid obstructive atherosclerosis

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
LV systolic dysfunction	Carotid ultrasound	Diagnostic Testing

Primary Outcome Measures

Name	Time	Method
Diagnostic accuracy for severe CAD	1 Day

Secondary Outcome Measures

Name	Time	Method
Diagnostic accuracy for significant CAD	1 Day