Comparative Study between Platelet-Rich Plasma, Corticosteroids and Perineural Dextrose local Injections for Treatment of Carpal Tunnel Syndrome
- Conditions
- Musculoskeletal Diseases
- Registration Number
- PACTR202310697176998
- Lead Sponsor
- Ain Shams University Faculty of Medicine
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 60
Patients included in the study were diagnosed with mild and moderate idiopathic carpal tunnel syndrome
With clinical symptoms for at least 3 months, and
According to the electrophysiological studies classification of carpal tunnel syndrome into mild, moderate as follows:
Mild CTS:
Prolonged distal motor latency( DML) but less than 150% of the highest normal value (5.4 ms);
Slowed sensory nerve conduction velocity (SNCV) but greater than 75% of the lowest normal value (30.1 m/s), Reduced compound muscle action potential (CMAP) or sensory nerve action potential (SNAP) amplitude but greater than 75% of the lowest normal value (CMAP: 3.9 mV, SNAP: 6.1 mV),
Mildly increased polyphasic waves or duration of motor units action potential (MUAPs) in electromyography (EMG) tests.
Moderate CTS:
Prolonged distal latencies at the range of 150% to 200% of the highest normal value (5.4–7.2 ms),
Slowed SNCV at the range of 50% to 75% of the lowest normal value (20–30 m/s),
Reduced CMAP or SNAP amplitude at the range of 50% to 75% of the lowest normal value (CMAP: 2.5–3.8 mV, SNAP: 4.0–6.0 mV)
Markedly increased polyphasic waves or duration of (MUAPs) in EMG tests.
Patients with a history and symptoms consistent with:
Severe carpal tunnel syndrome (wasting of thenar muscles)
Cervical radiculopathy
Thoracic outlet syndrome
Brachial plexopathies
Secondary CTS e.g.:
Diabetes mellitus
Rheumatoid arthritis
Myxedema
Acromegaly
Pregnancy
Oral contraceptive pills intake
Fracture or dislocation of carpal bone
Patient on chemotherapy or radiotherapy or cardiac drugs
Peripheral median nerve trauma
Patients with carpal tunnel syndrome who underwent surgical operation
Patients with coagulation disorders, Seizure disorders and severe psychiatric illness
Renal and liver impairment
Skin diseases at site of injection.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The result of this study may determine which treatment may be more beneficial for treatment of carpal tunnel syndrome
- Secondary Outcome Measures
Name Time Method All of the three studied groups (corticosteroids, perineural dextrose and platelet rich plasma) have shown a great result regarding improving in clinical examination, clinical assessment scales, nerve conduction studies and improving in neuromuscular ultrasound results of carpal tunnel syndrome with favorable results of corticosteroids group over perineural dextrose group and platelet rich plasma group.