Changes in brain communication and cognition in depressive patients who undergo electroconvulsive therapy (ECT) compared to treatment as usual (TAU)

Recruiting

• Conditions: F31; F32; F33; Bipolar affective disorder; Depressive episode; Recurrent depressive disorder

• Registration Number: DRKS00033460
• Lead Sponsor: Klinik und Poliklinik für Psychiatrie und Psychotherapie der Universität Regensburg

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2024-02-01
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 31

Inclusion Criteria

Inpatients with a depressive episode (ICD-10 F31, F32, F33;
HAMD-21: =17)
- Patients will only be included in the study after the study procedure has been explained in full and in detail and they have given their informed consent in writing

Exclusion Criteria

- Pregnant or breastfeeding women
- Drug or alcohol addiction
- Dementia
- Depressive episode secondary to a somatic/neurological illness or substance dependence
- Severe concomitant neurological or internal illness that may falsify the test results (e.g. recent myocardial infarction, Cushing's disease, underlying rheumatic diseases)
- Other additional severe psychiatric comorbidities
- The patient is unable to understand the nature and scope of the study and is therefore unable to give consent.
- Inclusion not voluntary
- Regular systemic intake of steroids or non-steroidal anti-inflammatory drugs (NSAIDs)
- Incompatibility with MR measurement

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Comparison of ECT and TAU with regard to their antidepressant efficacy

Secondary Outcome Measures

Name	Time	Method
Investigation of ECT-induced changes in molecular correlates of depression