Influence of changes in brain activity during movement observation and execution on the recovery of motor function after stroke.

Completed

Conditions: cerebrovascular accident (CVA)
Stroke
10047075

Registration Number: NL-OMON37259

Lead Sponsor: Medisch Spectrum Twente

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 15

Inclusion Criteria

- First ever ischemic stroke
- Unilateral cortical and/or subcortical stroke
- Stroke < 1 week ago
- Some motor dysfunction of the arm/hand (MRC < 5)
- Age between 18 and 80 years

Exclusion Criteria

- Other (pre-existing) neurological diseases (e.g. epilepsy, tumor, paralysis)
- Autism spectrum disorders, PDD, schizophrenia (or history of schizophrenia)
- Instable medical health situation (cardiovascular and/or neurological)
- Uncompensated hemineglect or cognitive disabilities, resulting in misunderstanding or incapability of executing instructions given
- Uncorrected visual problems, i.e. not able to observe the movie on the screen

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The correlation between changes in motor control and motor function and<br /><br>cortical activity is measured by comparing the scores of the grip strength<br /><br>(motor control) and the Fugl-Meyer motor assessment (motor function) with the<br /><br>changes in activity of the cortex. The activity of the brain is summarized in<br /><br>topoplots showing the degree of (de)synchronization by a colorscale projected<br /><br>on a headmodel. Change of activity of the cortex is quantified by calculating<br /><br>the event related synchronization (i.e. the difference in power of the EEG<br /><br>between the resting and the action condition), and the Brain Symmetry Index<br /><br>(i.e. the symmetry of the activity between the two hemispheres).</p><br>

Secondary Outcome Measures