Brain Activity During Attempted Movement in Late-Stage ALS: an fMRI Study
Recruiting
- Conditions
- ALSParalysis10012303
- Registration Number
- NL-OMON52876
- Lead Sponsor
- niversitair Medisch Centrum Utrecht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 27
Inclusion Criteria
- Aged 18 or older
- Clinical diagnosis of ALS or PLS
- No or only minimal and non-functional voluntary movement in the dominant hand
- Ability to lie flat on the back for one hour without respiratory difficulties
or significant saliva build-up
- Oral consent for the willingness to practice tasks at home before the
hospital visit (during which formal informed consent will be given; for more
info, see section 11)
- Reliable communication channel that can be used during the scan for yes-no
communication
- A score of at least 70% correct on the study understanding questionnaire
Exclusion Criteria
- Noncompliance with MRI safety check list
- Anxiety in the scanner/claustrophobia
- Pregnancy
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The main endpoint will be the classification accuracy of different movements<br /><br>based on sensorimotor cortex brain activity. </p><br>
- Secondary Outcome Measures
Name Time Method <p>Whether there are movements that are more easily differentiated based on brain<br /><br>activity, and the effect of late-stage ALS on the brain.</p><br>