The brain activity and motor performance during obstacle-crossing gait and effects of motor and cognition complex training - Study of Parkinson's disease with or without mild cognitive impairment (Part II)
Phase 2
Recruiting
- Conditions
- Parkinson's disease with or without mild cognitive impairments diseaseMild cognitive impairment
- Registration Number
- TCTR20210420003
- Lead Sponsor
- ational Yang Ming Chiao Tung University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 72
Inclusion Criteria
Parkinson's disease without cognitive impairment: 1) Diagnosed with idiopathic PD by a neurologist, 2) Hoehn and Yahr stage I to III, 3) Receive regular medication for treating Parkinson's disease, e.g., Levodopa, 4) >3 months of stable anti-Parkinson's medication, 5) Walk 1 min independently without assistive device, 6) Correctly respond to visual and auditory information, 7) Mini-mental state examination (MMSE) >=24, and 8) 20-80 years old Parkinson's disease with cognitive impairment: same as above, as well as 9) Montreal Cognitive Assessment (MoCA) <26
Exclusion Criteria
All participants: 1) unstable health condition, and 2) any orthopedic, neurological, or psychological disease affecting participation
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Brain activity assess after enrollment functional near-infrared spectroscope (fNIRS),Obstacle-crossing performance assess after enrollment GaitRite system,Obstacle-crossing gait assess after enrollment Gait up
- Secondary Outcome Measures
Name Time Method Global cognitive function assess after enrollment Montreal Cognitive Assessment,Executive function assess after enrollment Verbal Fluency Test,Attention assess after enrollment Digit Span Test,Visuospatial assess after enrollment Rey Osterrieth Complex Figure test,Usual walking performance assess after enrollment Gait up,Balance assess after enrollment Timed up and go,Motor symptom assess after enrollment Unified Parkinson's Disease Rating Scale-Part III,Falls risk assess after enrollment Falls Efficacy Scale International,Quality of life assess after enrollment Parkinson's disease questionnaire-39 item