The brain activity and motor performance during obstacle-crossing gait and effects of motor and cognition complex training - Study of Parkinson's disease with or without mild cognitive impairment (Part I)

Completed

• Conditions: Parkinson' s disease with or without mild cognitive impairment; s disease; Mild cognitive impairment

• Registration Number: TCTR20210420001
• Lead Sponsor: ational Yang Ming Chiao Tung University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2021-04-20
• Study Completion: 2023-03-03
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

Parkinson's disease without cognitive impairment: 1) Diagnosed with idiopathic PD by a neurologist, 2) Hoehn and Yahr stage I to III, 3) Receive regular medication for treating Parkinson's disease, e.g., Levodopa, 4) >3 months of stable anti-Parkinson's medication, 5) Walk 1 min independently without assistive device, 6) Correctly respond to visual and auditory information, 7) Mini-mental state examination (MMSE) >=24, and 8) 20-80 years old
Parkinson's disease with cognitive impairment: same as above, as well as 9) Montreal Cognitive Assessment (MoCA) <26
Healthy elderly: 1) Walk 1 min independently without assistive device, 2) Mini-mental state examination (MMSE) >=24

Exclusion Criteria

All participants: 1) unstable health condition, and 2) any orthopedic, neurological, or psychological disease affecting participation

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Brain activity assess after enrollment functional near-infrared spectroscope (fNIRS),Obstacle-crossing performance assess after enrollment GaitRite system,Obstacle-crossing gait assess after enrollment Gait up

Secondary Outcome Measures

Name	Time	Method
Global cognitive function assess after enrollment Montreal Cognitive Assessment,Executive function assess after enrollment Verbal Fluency Test,Attention assess after enrollment Digit Span Test,Visuospatial assess after enrollment Rey Osterrieth Complex Figure test,Usual walking performance assess after enrollment Gait up,Balance assess after enrollment Timed up and go,Motor symptom assess after enrollment Unified Parkinson's Disease Rating Scale-Part III,Falls risk assess after enrollment Falls Efficacy Scale International