Tri-model system of [18F]FDG-PET, fMRT and HD-EEG to study state networks
- Conditions
- G40Epilepsy
- Registration Number
- DRKS00014276
- Lead Sponsor
- niversitätsklinikum Tübingen, Radiologische Klinik, Nuklearmedizin & Molekulare Bildgebung
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 53
20 male or female patients with epilepsy having a clinical indicated [18F]FDG-PET examination, and 20 age- and gender-matched healthy volunteers.
For both groups:
- non-smoker,
- age =18 years,
- BMI 20-35,
- written informed consent.
- possible cardiovascular diesease
- moderate to severe intellectual debility
- physical or mental dependence, or other psychiatric diseases
- repeated cerebral ischemia, repeated craniocerebral trauma, or rather encephalitis in anamnesis
- positive familiy-anamnesis bearing neurodegenerative diseases
- surgery during last 3 month
- allergy
- contra-indications for MRT
- underage person or limited contractual capability
- parallel participation in other clinical studies
- job-related or other radiation exposure >15mSv/a
- precnancy or breast-feeding women
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The primary goal of the study is to gain more insight in complex brain networks using simultaneous [18F]FDG-PET/MR in combination with fMRI, and EEG.<br>Network-data (resting-stage as well as task-stage) from patients with epilepsy will be acquired and subsequently compared to the data of healthy volunteers (age- and gender-matched).
- Secondary Outcome Measures
Name Time Method Do [18F]FDG, fMRI, and EEG show convergent results for physiological, task-related network-activation? Which one and are this effects quantifiable?<br>Do [18F]FDG, fMRI, and EEG show convergent results for phathological network-dysfunction in epilepsy? Are this results useful for the development of new therapy approaches?<br><br>