Exercise during mild hypoxia exposure to reverse impaired glucose metabolism in overweight and obese humans - The HYTRIM study

niversiteit Maastricht0 sites11 target enrollmentTBD

Overview

No summary available.

Registry

who.int

Start Date

TBD

End Date

December 18, 2020

Last Updated

2 years ago

Study Type

Interventional

Sponsor

•Male subjects between the age of 30\-70 years have to be overweight or obese
•(BMI \>\<\= 28 kg/m2\), with impaired glucose homeostasis determined by OGTT (2h
•glucose: \>7\.8 \* 11\.1 mmol/L and/or fasting glucose 5\.6 \- 6\.9 mmol/L). In
•addition, subjects have to be weight\-stable for at least 3 months prior to
•participation (no change in bodyweight: \<3kg change).

•Subjects will be excluded from participation when one or more of the following
•aspects are present: cardiovascular disease (determined by questionnaire, blood
•pressure (Subjects with moderate to severe hypertension (grade 2 or 3 based on
•WHO criteria) will be excluded from participation in this study (SBP \> 160
•mmHg, DBP \> 100 mmHg)) and an electrocardiogram (ECG)), type 2 diabetes
•mellitus, cancer, asthma, bronchitis, chronic obstructive pulmonary disease
•(COPD), lung fibrosis, obstructive sleep apnea (OSAS), use of oxygen at home
•situation, resting SpO2 \*93%, abnormal pre\-bronchodilator forced expiratory
•volume (FEV1\) and forced vital capacity (FVC) (based on spirometry), liver or
•kidney malfunction (determined based on ALAT and creatinine levels,