NL-OMON49775已完成不适用
Exercise during mild hypoxia exposure to reverse impaired glucose metabolism in overweight and obese humans - The HYTRIM study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 11
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •Male subjects between the age of 30-70 years have to be overweight or obese
- •(BMI ><= 28 kg/m2), with impaired glucose homeostasis determined by OGTT (2h
- •glucose: >7.8 * 11.1 mmol/L and/or fasting glucose 5.6 - 6.9 mmol/L). In
- •addition, subjects have to be weight-stable for at least 3 months prior to
- •participation (no change in bodyweight: <3kg change).
排除标准
- •Subjects will be excluded from participation when one or more of the following
- •aspects are present: cardiovascular disease (determined by questionnaire, blood
- •pressure (Subjects with moderate to severe hypertension (grade 2 or 3 based on
- •WHO criteria) will be excluded from participation in this study (SBP > 160
- •mmHg, DBP > 100 mmHg)) and an electrocardiogram (ECG)), type 2 diabetes
- •mellitus, cancer, asthma, bronchitis, chronic obstructive pulmonary disease
- •(COPD), lung fibrosis, obstructive sleep apnea (OSAS), use of oxygen at home
- •situation, resting SpO2 *93%, abnormal pre-bronchodilator forced expiratory
- •volume (FEV1) and forced vital capacity (FVC) (based on spirometry), liver or
- •kidney malfunction (determined based on ALAT and creatinine levels,
- •respectively), disease with a life expectancy shorter then 5 years (subjects
- •will be asked if they have a disease, which could lead to death within 5 years,
- •the life expectancy will be estimated by the investigator) diagnosis, lactose
- •intolerance, abuse of products (alcohol consumption > 15 units/week), smoking,
- •plans to lose weight (subjects will be asked if they have weight loss plans
- •(e.g. to increase their physical activity level or change diet): a positive
- •answer will lead to exclusion) or follow a hypocaloric diet, participation in
- •organized sports activities more than three hours a week, use of high doses of
- •anti-oxidant vitamins (A, C, E, *-carotene; a standard multi-vitamin capsule is
- •permitted if less than 800*g/day Vit A, 60mg/day Vit C, 10mg/day Vit E and
- •400*g/day *-carotene) or use of any medication that influences glucose
- •metabolism and inflammation. Furthermore, shift-workers will be excluded from
- •participation as well.
研究者
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