ROTEM Assessment of Modern Crystalloid, Hydroxyethyl Starch and Gelatin Effect on Coagulation
- Conditions
- Coagulopathy
- Interventions
- Other: hydroxyethyl starch
- Registration Number
- NCT03674684
- Lead Sponsor
- University Hospital, Motol
- Brief Summary
Modern crystalloid and colloid solutions are balanced solutions which are increasingly used in perioperative period. However, studies investigating their negative effect on whole blood coagulation are missing. The aim of our study was to assess the effect of modern balanced crystalloid and colloid solutions on whole blood coagulation in vivo using rotational thromboelastometry.
- Detailed Description
Blood samples were obtained from 30 patients during knee arthroscopy before and after administration of 500 ml of modern balanced crystalloid, hydroxyethyl starch (HES) or gelatin. Rotational thromboelastometry (EXTEM, INTEM and FIBTEM tests) were performed to assess negative effect of fluid solutions on whole blood coagulation.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 30
- healthy patients undergoing knee arthroscopy
- receiving antiplatelet drugs
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description gelatin hydroxyethyl starch Patients who received gelatin crystalloids hydroxyethyl starch Patients who received crystalloids hydroxyethyl starch hydroxyethyl starch Patients who received hydroxyethyl starch
- Primary Outcome Measures
Name Time Method thromboelastometry assessment of coagulation 3 months ROTEM tests- clotting time in seconds, Maximal clot firmness in mm, alpha angle of in degree of following tests EXTEM, INTEM, FIBTEM
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
University Hopital Motol
🇨🇿Prague, Czech Republic