Respiratory and Quadriceps Muscle Fatigability After an ICU Acquired Weakness

Completed

• Conditions: ICU Acquired Weakness

• Registration Number: NCT05396066
• Lead Sponsor: Groupe Hospitalier du Havre

Brief Summary

Muscle dysfunction can be lead to poor outcomes moreover ICU muscle weakness recovery are not correctly described.

The investigators aimed to assess the ability for quadriceps or respiratory muscles to repeat an effort at a maximal loading.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2022-03-10
• Study First Submitted QC: 2022-05-24
• Study First Posted: 2022-05-31
• Study Start: 2022-06-15
• Primary Completion: 2023-12-31
• Study Completion: 2024-02-01
• Status Verified: 2024-07
• Last Update Submitted: 2024-07-10
• Last Update Posted: 2024-07-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• Mechanically ventilated at least at 24 Hours
• Maximal inspiratory pressure < 30 centimeter of water
• MRC score < 48/60

Exclusion Criteria

• Age < 18 years
• Patients with neurological pathology or pre existing neuromuscular dysfunction
• Patient unable to walk 50 meters before ICU admission
• Patient with a thoracic or abdominal surgery
• Inability to carry out maximal voluntary contraction

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change in Respiratory muscle strength	One day	Respiratory muscle strength will be assessed by Maximal Inspiratory pressure in centimeter of water. The measure will carry out by an electronical manometer
Change in quadriceps muscle strength	One day	Quadriceps muscle strength will be assessed by Maximal Voluntary contraction of the quadriceps in Newton. The measure will carry out by an electronical dynamometer

Trial Locations

Locations (1)

Groupe Hospitalier du Havre; 🇫🇷 Montivilliers, Groupe Hospitalier Du Havre, France