Usage of Desmopressin fo Improving Nocturnal Enuresis in Patients After Radical Cystectomy With Orthotopic Bladder Reconstruction
试验速览
- 阶段
- 4 期
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Rate of improvement in Nocturnal incontinence
研究概览
简要总结
The purpose of this study is to prospectively assess whether Desmopressin, given for a period of month to patients after radical cystectomy with orthotopic bladder reconstruction, improves and lowers the rate of nocturnal enuresis.
详细描述
We will prospectively assess the utilization of Desmopressin in improving nocturnal enuresis in patients after radical cystectomy with orthotopic bladder reconstruction.
Patients after radical cystectomy with neobladder reconstruction will be given Desmopressin 0.1 mg once a day for a duration of one month.
Before beginning treatment patients will be given the NNES-Q questionnaire to assess severity of nocturnal enuresis.
At the end of treatment, the same questionnaire will be given to all patients to assess if nocturnal enuresis improved.
Sodium levels will be tested before treatment, 2 weeks after beginning treatment and at the end of treatment.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age above 18
- •Able to give informed consent
- •Patients afte radical cystectomy with orthotopic bladder reconstruction with night time incontinence
排除标准
- •Patients with after radical cystectomy with orthotopic bladder reconstruction with daytime urinary incontinence
- •Patients already treated with Desmopressin due to other reasons.
- •Patients with an allergy or insensitivity to Desmopressin.
- •Patients with known hyponatremia
- •Patients with severe chronic renal failure and creatinine clearance of below 50 cc/sec.
- •Patients with severe congestive heart failure
- •Patients with active urinary tract infection
- •Patients taking drug therapy which can interact with Desmopressin and affect it's action.Examples include Diuretics, Tricyclic antidepressants, Carbamezapine and Chlorpropamide AND Indomethacin.
- •Patients with an indwelling urinary catheter.
研究组 & 干预措施
Desmopressin
干预措施: Desmopressin (Drug)
结局指标
主要结局
Rate of improvement in Nocturnal incontinence
时间窗: One month
次要结局
未报告次要终点