Evaluation of Influenza Vaccination and Treatment With ACEI and ARB in the Evolution of SARS-CoV2 Infection
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 3,000
- 试验地点
- 1
- 主要终点
- hospital output
研究概览
简要总结
Some authors have proposed the use of the flu vaccine to reduce the severity of COVID-19 cases, while some have proposed the use of ACE Inhibitors (ACEI) or Angiotensin Receptor blockers (ARB), since this virus shares hemagglutinin as a transmission mechanism and acts on the ACE2 enzyme during infection.
Other authors described how none of the elderly patients receiving antihistamines and azythromycin in two nursing homes in Toledo -Spain- during the first wave died or needed hospital admission, even considering that 100% of residents had a positive serological test after that wave. Other authors have described a positive evolution in patients receiving amantadine for their Parkinson's disease.
The aim is to evaluate whether the admitted patients who are previously vaccinated or those who were already receiving these treatments showed a better evolution.
详细描述
The number COVID cases would be related to hospital admissions. Among hospital admissions, the number of previous treatments, the length of admission, the need or not of the Intensive Care Unit (ICU) and their final status (survivors or non survivors) would be studied.
If patients that previously received the influenza vaccine or treated with ACEI, ARB, antihistamines or amantadine showed a better evolution, it would be proposed to extend vaccination and the inclusion of ACE inhibitors, ARB, antihistamines or amantadine in the treatment of infection.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Hospital Admissions at the Hospital of Terrassa from March 1, 2020 for any cause.
排除标准
- •For comparison of percentage of Influenza vaccination, ACEI and ARB vs general population, patients from outside the reference area of the Terrassa Health Consortium would be excluded.
研究组 & 干预措施
Hospital admissions, postcovid syndrome and thrombosis among COVID cases in CST population
Observation of patient characteristics of hospital incomes in Hospital of Terrassa from March 1, 2020.
No intervention is performed.
干预措施: Antihistamine (Drug)
Hospital admissions, postcovid syndrome and thrombosis among COVID cases in CST population
Observation of patient characteristics of hospital incomes in Hospital of Terrassa from March 1, 2020.
No intervention is performed.
干预措施: Amantadine (Drug)
Hospital admissions, postcovid syndrome and thrombosis among COVID cases in CST population
Observation of patient characteristics of hospital incomes in Hospital of Terrassa from March 1, 2020.
No intervention is performed.
干预措施: ACEI (Drug)
Hospital admissions, postcovid syndrome and thrombosis among COVID cases in CST population
Observation of patient characteristics of hospital incomes in Hospital of Terrassa from March 1, 2020.
No intervention is performed.
干预措施: ARB (Drug)
Hospital admissions, postcovid syndrome and thrombosis among COVID cases in CST population
Observation of patient characteristics of hospital incomes in Hospital of Terrassa from March 1, 2020.
No intervention is performed.
干预措施: Influenza vaccine and COVID (Other)
Evolution of COVID cases in patients receiving antihistamines
COVID cases, hospital admissions, postcovid syndrome, thrombosis and deaths related to COVID from march 1, 2020 in patients of the participating institutions receiving chronic treatment with antihistamines.
No intervention is performed.
干预措施: Antihistamine (Drug)
Evolution of COVID cases in patients receiving amantadine.
COVID cases, hospital admissions, postcovid syndrome, thrombosis and deaths related to COVID from march 1, 2020 in patients of the participating institutions receiving chronic treatment with amantadine.
No intervention is performed.
干预措施: Amantadine (Drug)
结局指标
主要结局
hospital output
时间窗: from March 1, 2020.
exitus vs hospital output
次要结局
- hospital stay(From March 1, 2020.)
研究者
Anna Puigdellívol-Sánchez
M.D., Ph.D.
Consorci Sanitari de Terrassa