Dynamic modelling of resilience: Observational multicenter study.
- Conditions
- Stress-related mental health problemsStress-related psychopathy10002861
- Registration Number
- NL-OMON49554
- Lead Sponsor
- Radboud Universitair Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 57
Participants are healthy students (18-25 years old) who have experienced at
least three life events which were each evaluated as burdening. Participants
have a total GHQ (i.e. general health questionnaire) score * 20. Volunteers are
proficient in the Dutch language.
The participant currently meets criteria of a relevant psychiatric disorder
except for a mild depressive episode (ICD F32.1), tobacco dependence (ICD F12)
and substance abuse as established using the Mini-International
Neuropsychiatric interview. The participant has met criteria for a relevant
psychiatric disorder except for a mild depressive episode (ICD F32.1), tobacco
dependence (ICD F12), and a substance abuse in the past 9 months. The
participant has ever been diagnosed with a severe mental or organic disorder
that affects neurodevelopment due to its pathological mechanism or treatment.
The subject*s body mass index is lower than 18 or higher than 27. The
participant is not eligible for functional magnetic resonance imaging. The
participant took any psychoactive substances 4 weeks prior to Baseline Day 1
and the MRI appointment. The participant is not eligible to wear the Chill+.
The participant is not free of COVID-19 related symptoms.The participant is
currently in psychiatric treatment. The participant receives hormonal treatment
other than oral contraceptives and/or takes steroids.
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The main study parameter is dynamic stress resilience (i.e. mental health<br /><br>maintenance despite stressor exposure), as measured with a residuals-based<br /><br>stressors reactivity score. </p><br>
- Secondary Outcome Measures
Name Time Method <p>Several parameters are studied to unravel the time-varying, individually<br /><br>variable and interactive engagement of the biological, psychological and social<br /><br>resilience factors, including: biological parameters, psychological<br /><br>questionnaires, neuroimaging, and ecological momentary & physiological<br /><br>assessments.</p><br>