Effect of intraoperative magnesium sulphate infusion on total anaesthetic requirement and postoperative analgesia in craniotomy patients: A prospective interventional study
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 74
- 试验地点
- 1
- 主要终点
- Effect of magnesium sulphate on reduction in post operative rescue analgesic requirement and post operative pain in the study group
研究概览
简要总结
AIM : This study has to evaluate effect of MgSO4 on total anaesthetic requirement intraoperatively as well as post operative total analgesic requirement in craniotomy patients .
OBJECTIVE : Primary - Comparing total post operative rescue analgesic (tramadol) requirement in patients on MgSO4 infusion during craniotomy to that of patients not on MgSO4 infusion during craniotomy .
Secondary : 1. Comparing post operative VAS score in both the groups for 24 hours .
- Comparing total dose of Propofol and Vecuronium required in the study and control group till the end of surgery .
研究设计
- 研究类型
- Interventional
- 分配方式
- Not Applicable
- 盲法
- Participant Blinded
入排标准
- 年龄范围
- 19.00 Year(s) 至 59.00 Year(s)（—）
- 性别
- All
入选标准
- •ASA Grade 1 and 2 patients Elective craniotomies (both supratentorial and posterior fossa surgeries) GCS 15.
排除标准
- •ASA Grade III and IV Pregnant female Patients with neuromuscular renal cardiovascular 0r hepatic insufficiency BMI<18.5 or > 24.9kg/m2 Allergy to the study drugs Those on treatment with calcium channel blockers or magnesium Patients who will be shifted on ventilator post craniotomy Anaesthesia time more than 5 hrs preventing excessive infusion of MgSO4 Any other mental or physical illness rendering them incapable of answering pain score Patient on any previous chronic pain medications like gabapentin or pregabalin Trauma and emergency craniotomies.
结局指标
主要结局
Effect of magnesium sulphate on reduction in post operative rescue analgesic requirement and post operative pain in the study group
时间窗: start magnesium sulphate after induction till closure of dura.Post operative pain will be assessed at 1st hr 2nd hr 4th hr 6th hr 8th hr 12th hr 16th hr 20th hr and 24 hrs
次要结局
- Effect of MgSO4 on reduction of intraop dose of Propofol and Vecuronium during surgery(start magnesium sulphate after induction till closure of dura)