Effect of intraoperative magnesium sulphate in craniotomy patients

Not yet recruiting

Conditions: Other specified disorders of central nervous system, (2) ICD-10 Condition: G968||Other specified disorders of central nervous system,

Registration Number: CTRI/2023/03/050300

Lead Sponsor: Dr Manoj Kumar Giri

Brief Summary: AIM : This study has to evaluate effect of MgSO4 on total anaesthetic requirement intraoperatively as well as post operative total analgesic requirement in craniotomy patients .

OBJECTIVE : Primary - Comparing total post operative rescue analgesic (tramadol) requirement in patients on MgSO4 infusion during craniotomy to that of patients not on MgSO4 infusion during craniotomy .

Secondary : 1. Comparing post operative VAS score in both the groups for 24 hours .

2. Comparing total dose of Propofol and Vecuronium required in the study and control group till the end of surgery .

Detailed Description: Not available

Recruitment & Eligibility

Status: Not Yet Recruiting

Sex: All

Target Recruitment: 74

Inclusion Criteria

ASA Grade 1 and 2 patients Elective craniotomies (both supratentorial and posterior fossa surgeries) GCS 15.

Exclusion Criteria

ASA Grade III and IV Pregnant female Patients with neuromuscular renal cardiovascular 0r hepatic insufficiency BMI<18.5 or > 24.9kg/m2 Allergy to the study drugs Those on treatment with calcium channel blockers or magnesium Patients who will be shifted on ventilator post craniotomy Anaesthesia time more than 5 hrs preventing excessive infusion of MgSO4 Any other mental or physical illness rendering them incapable of answering pain score Patient on any previous chronic pain medications like gabapentin or pregabalin Trauma and emergency craniotomies.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Effect of magnesium sulphate on reduction in post operative rescue analgesic requirement and post operative pain in the study group	start magnesium sulphate after induction till closure of dura.Post operative pain will be assessed at 1st hr 2nd hr 4th hr 6th hr 8th hr 12th hr 16th hr 20th hr and 24 hrs

Secondary Outcome Measures

Name	Time	Method
Effect of MgSO4 on reduction of intraop dose of Propofol and Vecuronium during surgery	start magnesium sulphate after induction till closure of dura

Trial Locations

Locations (1): Dr. Ram Manohar Lohia Institute of Medical Sciences
🇮🇳
Lucknow, UTTAR PRADESH, India
Dr. Ram Manohar Lohia Institute of Medical Sciences
🇮🇳Lucknow, UTTAR PRADESH, India
Dr Manoj Kumar Giri
Principal investigator
9044479649
drmanoj.giri@gmail.com