NCT01293422已完成4 期
PXR-aktivaation Vaikutukset Sokeri-, Kolesteroli- ja Hormonitasapainoon
适应症
干预措施
相关药物
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 12
- 试验地点
- 1
- 主要终点
- Glucose levels during oral glucose tolerance test
研究概览
简要总结
This clinical trial is designed to study the effects of pregnane X receptor activator rifampicin on the glucose, lipid and hormone homeostasis in healthy volunteers. The main hypothesis is that rifampicin raises postprandial glucose studied with oral glucose tolerance test. The study is a non-randomized, one-phase, open-label trial. Twelve subjects will be given 600 mg of rifampicin a day for a week. The main outcome measures are the changes in the glucose and insulin levels during oral glucose tolerance test.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy volunteer
- •Age 18-45 years
- •Body mass index 19-28
排除标准
- •Any continuous medication
- •Any significant disease
- •Allergy to rifampicin
- •Pregnancy and breast feeding
- •Fear of needles and previous difficult blood samplings
- •Substance abuse
- •Participation in another clinical drug trial within 1 month of enrollment
- •Use of soft contact lenses
研究组 & 干预措施
Rifampicin
Experimental
干预措施: Rifampicin (Drug)
结局指标
主要结局
Glucose levels during oral glucose tolerance test
次要结局
未报告次要终点
研究者
研究点 (1)
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