The role of the dopamine and opioid systems in pain-avoidance learning

Completed

• Conditions: scientific investigation of healthy subjects; healthy

• Registration Number: NL-OMON42474
• Lead Sponsor: niversiteit Leiden

Brief Summary

Trial is onging in other countries

Detailed Description

Not available

Study Timeline

• Study Completion: 2016-09-30
• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 91

Inclusion Criteria

Healthy adult subjects with no history of neurological disorder/disease or chronic pain, and no counter-indications to 3 Tesla MRI or to levodopa or naltrexone, and no personal relationship with the researchers will be included in this study. All participants will be right-handed native-Dutch speakers with normal vision or contact lenses.

Exclusion Criteria

Potential participants will be prescreened for contra-indications for 3 Tesla fMRI and levodopa/naltrexone, which include metal implants, heart arrhythmia, claustrophobia, glaucoma, hypertension and use of anti-depressants or psychotropic medication and possible pregnancy (in adult females). They will additionally be prescreened for head trauma, premature birth, learning disabilities, chronic pain, and history of neurological or psychiatric illness. Finally, left-handed
individuals will be excluded from the study because some left-handers have substantially different brain organization relative to right-handers.

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified