Modified Reporting of Positive Urine Cultures Collected From Long Term Care

Not Applicable

Completed

• Conditions: Asymptomatic Bacteriuria; Urinary Tract Infections
• Interventions: Behavioral: Modified Report

• Registration Number: NCT03554603
• Lead Sponsor: Memorial University of Newfoundland

Brief Summary

Asymptomatic bacteriuria (AB) is a condition in which bacteria are detected in urine culture without urinary symptoms. The inappropriate use of antibiotic treatment for AB selects bacterial flora to express resistance mutations. Reducing inappropriate antibiotic use for AB is difficult, since the microbiology laboratory cannot distinguish patients with AB. The investigators study will use a restricted laboratory report requesting the physician to call the laboratory for culture results. The restricted report may reduce the rate of inappropriate treatment of AB.

Detailed Description

Positive urine cultures during the study period will be randomized to restricted microbiology laboratory reporting or standard microbiology laboratory reporting. Physician or patient consent will not be collected. Patient records will be assessed by the investigator to determine if patients have AB or urinary tract infection. Physician antibiotic treatment decision in both groups will be collected.

Study Timeline

• Study First Submitted: 2018-06-01
• Study First Submitted QC: 2018-06-07
• Study First Posted: 2018-06-13
• Study Start: 2018-11-05
• Primary Completion: 2019-07-31
• Study Completion: 2019-07-31
• Results First Submitted: 2022-09-05
• Status Verified: 2023-07
• Results First Submitted QC: 2023-07-26
• Last Update Submitted: 2023-07-26
• Results First Posted: 2024-03-01
• Last Update Posted: 2024-03-01

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

1. Consecutive positive urine cultures collected from patients admitted to Long term care facilities will be included. All methods of urine collection will be included (midstream, in-and-out catheterization, indwelling catheter).

Exclusion Criteria

1. Positive urine cultures not collected from Long term care facility patients
2. Pregnancy
3. Antibiotic treatment at the time of collection
4. Patients known to have blood neutrophils <1.0 within 7 days of urine collection

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Modified Reporting	Modified Report	Microbiology laboratory will report "Positive urine cultures may represent asymptomatic bacteriuria or urinary tract infection. If urinary tract infection is suspected clinically, please call 777-xxxx (researcher mobile phone) for identification and susceptibility results"

Primary Outcome Measures

Name	Time	Method
Proportion of Asymptomatic Bacteriuria Treated With Antibiotics and Urinary Tract Infection Treated With Antibiotics	7 days	Number of Participants Who Received Appropriate Antibiotic Treatment

Trial Locations

Locations (1)

Health Sciences Center; 🇨🇦 Saint John's, Newfoundland and Labrador, Canada