Physiological and Biochemical Effects of Laparoscopic Anesthesia and Surgery
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 60
- 主要终点
- blood sugar, should measured and assessed with different groups
研究概览
简要总结
Laparoscopic surgery is widely used now. These benefits included many items, e.g. reducing post-operative pain, cosmetic the result was improved, and the patient also had more satisfaction for the patient and reduced hospital stay. This surgery involved insufflation of gas into the peritoneal cavity, producing pneumoperitoneum, and causing an increase in intra-abdominal pressure. The raised intraabdominal pressure of the pneumoperitoneum, the patient's position alteration, and the absorption of carbon dioxide into the abdomen have a direct effect on causing a change in physiology, especially in the cardiovascular and respiratory systems. These effects, as well as a direct effect of gas insufflation, may have significant effects on the patient especially if the patient has a comorbidity or is elderly.
详细描述
The objective of this study was to assess the technique used in laparoscopic surgery and their associated complications, including some hematological parameters, (these include blood pictures and liver enzymes), respiratory, (including the inspired and expired tidal volume, oxygen saturation, airway pressure, plateau pressure, and use of PEEP) cardiovascular system (including the systolic, diastolic, and mean blood pressure, heart rate)
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •elective abdominal surgery
- •a healthy, fit person
- •use of general anesthetics
- •use of pneumoperitoneum and CO2 insufflation
排除标准
- •emergency condition
- •patient with cardiovascular disease
结局指标
主要结局
blood sugar, should measured and assessed with different groups
时间窗: 5 minute during pre-operative and 15 minute post- operative period
blood sugar in mg/dl
end-tidal Co2, measured and compared statistically with other parameter
时间窗: perioperatively every 5 minute
End-tidal Co2 in CMH2O
blood pressure.
时间窗: during preoperative, 5 minute, intraoperative every five minute with post operative read after one hour
blood pressure in mmHg, pulse rate in beat per minute
AST and ALT liver enzymes were measured, by blood samples taken intravenously in the perioperative period
时间窗: 5 minute pre-operation and 5 minute postoperative
in unit/liter
pulse rate measured continuously during intra-operative and compared with other hemodynamic parameter
时间窗: 5 minute during preoperative, and continue every 5 minute in perioperatively
beat per minute (BPM)
次要结局
- measurement of body weight(measured preoperative period by 5 minute and post-operative during 15 minute)
研究者
Mohammed Abdulhameed
principal investigator
Tunis University