The Effect of Pnemoperitoneum on Intracranial Pressure and Cerebral Oxygenation During Laparoscopic Surgery According to Anesthesia Agents: Propofol Based Total Intravenous Anesthesia vs Desflurane Anesthesia
- Registration Number
- NCT02003768
- Lead Sponsor
- Yonsei University
- Brief Summary
The pneumoperitoneum during laparoscopic surgery have the potential to cause an increase of intracranial pressure (ICP). Previous studies have proposed that ultrasonographic measurements of the optic nerve sheath diameter (ONSD) correlate with signs of increased ICP. The aim of this study is to compare the effect of pnemoperitoneum on intracranial pressure and cerebral oxygenation during laparoscopic surgery according to anesthesia agents, propofol based total intravenous anesthesia (TIVA group) and desflurane anesthesia (Des group).
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- WITHDRAWN
- Sex
- All
- Target Recruitment
- Not specified
Inclusion Criteria
- Adult patients (20-80 years of age) scheduled for laparoscopic cholecystectomy undergoing general anesthesia
Exclusion Criteria
- Patients with previous history of neurologic disease, carotid disease, transient ischemic attack, ocular disease and ocular surgery
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description TIVA Propofol 2% Propofol (Fresofol®), Remifentanil 20mcg/cc (Ultiva®) Des Desflurane Desflurane (Suprane®), Remifentanil continuous infusion (20mcg/cc)
- Primary Outcome Measures
Name Time Method the ultrasonographic measurement of optic nerve sheath diameter baseline optic nerve sheath diameter measured by ultrasonography
- Secondary Outcome Measures
Name Time Method