Hemodynamic Effect of Nasal High-flow in Patients Suspected or Followed for a Precapillary Pulmonary Hypertension
- Conditions
- Pulmonary Hypertension
- Interventions
- Device: Nasal high-flow
- Registration Number
- NCT06079151
- Lead Sponsor
- ADIR Association
- Brief Summary
In this study, the investigators aim to describe the hemodynamic consequences of nasal high-flow measured during right heart catheterization and echocardiography. The research hypothesis is that nasal high-flow would increase cardiac output in patients with pulmonary hypertension. The concomitant echocardiography will allow to describe its sensibility to detect cardiovascular consequences of nasal high-flow.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 20
- patient addressed for right heart catheterization for pulmonary hypertension suspicion or follow-up.
- necessity of FiO2 >21% during right heart catheterization
- intracardiac shunt
- grade 4 tricuspid insufficiency
- complete arrhythmia due to atrial fibrillation
- Pregnant or breastfeeding women or women of childbearing age without an effective method of contraception
- protected adult patient (tutorship or curatorship)
- patient deprived of liberty by court or administrative decision
- refusal of patient participation or consent
- patient for whom the measurement of pulmonary arterial pressures during right heart catheterization is impossible
- patient for whom, during the etiological assessment of pulmonary hypertension, the diagnosis of precapillary pulmonary hypertension cannot be confirmed and classified in groups 1, 3 or 4.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description Nasal high-flow 30 L/min and then 50 L/min Nasal high-flow The patient will be placed successively under nasal high-flow 30 L/min during 20 min and then 50 L/min during 20 min. Nasal high-flow 50 L/min and then 30 L/min Nasal high-flow The patient will be placed successively under nasal high-flow 50 L/min during 20 min and then 30 L/min during 20 min.
- Primary Outcome Measures
Name Time Method Cardiac output During the intervention, at isotime Changes measured during cardiac catheterization under nasal high-flow 30 and 50 L/min
- Secondary Outcome Measures
Name Time Method cardiac output During the intervention, at isotime Changes measured during cardiac catheterization under nasal high-flow 30L/Min FiO2 21% as compared to room air
mean pulmonary arterial pressure During the intervention, at isotime Changes measured during cardiac catheterization under nasal high-flow 30 and 50 L/min
capillary wedge pressure During the intervention, at isotime Changes measured during cardiac catheterization under nasal high-flow 30 and 50 L/min
pulse oxygen saturation During the intervention, at isotime Changes measured during cardiac catheterization under nasal high-flow 30 and 50 L/min
capillary wedge pressure measured by catheterization and echocardiography. During the intervention, at isotime Concordance and correlation of hemodynamic parameters measured by catheterization and echocardiography.
cardiac output measured by catheterization and echocardiography. During the intervention, at isotime Concordance and correlation of hemodynamic parameters measured by catheterization and echocardiography.
pulmonary vascular resistance During the intervention, at isotime Changes measured during cardiac catheterization under nasal high-flow 30 and 50 L/min
central venous oxygen saturation During the intervention, at isotime Changes measured during cardiac catheterization under nasal high-flow 30 and 50 L/min
heart rate During the intervention, at isotime Changes measured during cardiac catheterization under nasal high-flow 30 and 50 L/min
systolic pulmonary arterial pressure During the intervention, at isotime Changes measured during cardiac catheterization under nasal high-flow 30 and 50 L/min
systolic arterial pressure During the intervention, at isotime Changes measured during cardiac catheterization under nasal high-flow 30 and 50 L/min
diastolic arterial pressure During the intervention, at isotime Changes measured during cardiac catheterization under nasal high-flow 30 and 50 L/min
mean arterial pressure During the intervention, at isotime Changes measured during cardiac catheterization under nasal high-flow 30 and 50 L/min
systolic ejection volume During the intervention, at isotime Changes measured during cardiac catheterization under nasal high-flow 30 and 50 L/min
Consequences of nasal high-flow 50 and 30 L/min FiO2 21% on echocardiographic parameters. During the intervention, at isotime Cardiac output, inferior vena cava diameter and collapsibiliy, systolic pulmoanry arterial pressure, tricuspid regurgitation velocity,tricuspid annular plane systolic excursion, right ventricule strain, tricuspid S wave, right on left ventricular telediastolic surface ratio, left ventricular ejection fraction, mitral doppler, mitral S wave, respiratory variability of E mitral wave
systolic pulmonary arterial pressure measured by catheterization and echocardiography. During the intervention, at isotime Concordance and correlation of hemodynamic parameters measured by catheterization and echocardiography.
right atrial pressure measured by catheterization and echocardiography. During the intervention, at isotime Concordance and correlation of hemodynamic parameters measured by catheterization and echocardiography.
Right atrial pressure During the intervention, at isotime Changes measured during cardiac catheterization under nasal high-flow 30 and 50 L/min
diastolic pulmonary arterial pressure During the intervention, at isotime Changes measured during cardiac catheterization under nasal high-flow 30 and 50 L/min
respiratory rate During the intervention, at isotime Changes measured during cardiac catheterization under nasal high-flow 30 and 50 L/min
Trial Locations
- Locations (1)
ROUEN university hospital
🇫🇷Rouen, France