Diversity and Dynamic Stability of the Ocular Surface Microbiome
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- To catalog the bacteria and other micro-organisms that are naturally found on the eye surface.
研究概览
简要总结
The purpose of this study is to collect samples from the surface of eyelids to try to grow and identify bacteria or fungus that might be present, and to try to understand why people have dry eye symptoms.
详细描述
"Dry eye" is a very common eye condition, which may or may not be caused by specific microorganisms that live on the surface of the eye. In this study, a combination of tissue culture and molecular biology techniques will be used to identify every microbe (bacteria, fungus, or virus) on the surface of eyes of people with dry eye syndrome, as well as a 'control' group of people who don't have dry eye disease.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Subjects with ocular surface discomfort with an Ocular Surface Disease Index score of greater than 60
- •Subjects with and Ocular Surface disease Index score less than 30
- •Males and females age 18 or older
排除标准
- •Contact lens wear
- •Use of oral or topical antibiotics in past 6 months
- •Use of prescription eye medication in past 6 months
- •Penetrating ocular or keratoplasty surgery in last 12 months
- •Children under the age of 18
结局指标
主要结局
To catalog the bacteria and other micro-organisms that are naturally found on the eye surface.
时间窗: 6 months
次要结局
未报告次要终点
研究者
Russell Van Gelder
Professor of Ophthalmology
University of Washington