Advanced glycation end products (AGE) measured by skin autofluorescence and the association with vascular compliance in children with type 1 diabetes.
Completed
- Conditions
- Type 1 Diabetes Mellitus1001265310003216
- Registration Number
- NL-OMON40440
- Lead Sponsor
- MCG
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 280
Inclusion Criteria
type 1 diabetes
Exclusion Criteria
Other forms of diabetes (type 2, MODY, CFRD etc.)
Local skin disease of the lower arm obviating skin autofluorescence measurement
Very dark skin influencing skin autofluorescence measurement (reflectance <8%; Fitzpatrick skin type V-VI)
Arm too small to cover the window of the AGE reader
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>AGE-measurement, vascular compliance and endothelial markers in blood.</p><br>
- Secondary Outcome Measures
Name Time Method <p>Duration of diabetes, HbA1c, BMI, body composition, smoking, lipid<br /><br>concentrations, microalbuminuria, retinopathy, insulin dosage per kg body<br /><br>weight, family history of cardiovascular disease, hypertension,<br /><br>hypercholesterolemie or diabetes.</p><br>