Accumulation of advanced glycation endproducts in patients with systemic amyloidosis.

Completed

• Conditions: Amyloidosis; Eiwitvouwziekte; Protein folding disease

• Registration Number: NL-OMON42888
• Lead Sponsor: Reumatologie en Klinische Immunologie

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 28 February 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 100

Inclusion Criteria

ATTR amyloidosis:
- Written informed consent
- Patient has genotyped TTR mutation with diagnosis of ATTR (congo red positive tissue
specimen) or wild-type ATTR amyloidosis (confirmed TTR amyloid by immunohistochemistry
without mutation in TTR gene).;AL amyloidosis:
- Written informed consent
- Congo red positive tissue specimen and the presence of a clonal plasma cell dyscrasia. Plasma
cell dyscrasia is diagnosed when a free kappa or lambda light chain is detected in serum of urine
by immunofixation electrophoresis or when a relative excess of cells producing one of the two light
chains is detected in bone marrow.

Exclusion Criteria

None

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Skin autofluorescence as measure of AGE accumulation.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Skin autofluorescence will be related to:<br /><br>- Amyloid load in fat tissue (semi-quantitative scored Congo red-stained<br /><br>abdominal fat smears)<br /><br>- SAP-scintigraphy as a mark of amyloid load of the body.<br /><br>- Levels of C-reactive protein, creatinine and HbA1c.</p><br>