Biomarker Expression, predicts risk of re-AMputation, impaired woundhealing and secundairy systemic cardiovascualr events, in patients with endstage peripheral atherosclerotic disease undergoing leg amputation due to advanced atherosclerotic disease. The BEAM study.

Withdrawn

• Conditions: Atherosclerosis; Critical Limb Ishemia; 10040795; 10003216

• Registration Number: NL-OMON38319
• Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Withdrawn
• Sex: Not specified
• Target Recruitment: 200

Inclusion Criteria

Patients between 18-99 years old with critical limb ischemia and without medical treatment options, revascularization possibilities or exercise treatment.

Exclusion Criteria

Younger than 18 years old, HIV positive patients

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The study parameters have not been defined yet, a number of different proteins<br /><br>will be investigated as well as histology including vessel density. These<br /><br>parameters will be related to patient and follow-up data.<br /><br><br /><br>Follow-up parameters include:<br /><br>1: re-amputation withing 3 years following primary amputation<br /><br>2: woundinfection<br /><br>3: duration of correct woundhealing ( days following surgery, within 6 weeks<br /><br>after surgery)</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>A: Acute other manifestations of atherosclerosis (myocardial infarction,<br /><br>cerbrsl infarction and peripheral intervention)</p><br>