Intrathecal Morphine in Knee Arthroplasty

Not Applicable

Completed

• Conditions: Pain, Postoperative; Arthroplasty, Replacement, Knee
• Interventions: Drug: intra thecal morphine

• Registration Number: NCT00695045
• Lead Sponsor: University College Hospital Galway

Brief Summary

This study is designed to explore the efficacy lower doses of intra-spinal morphine for pain relief and side effect profiles of same in the setting of Total Knee Replacement.We hypothesized that a dose greater than that used in Total Hip Replacement was needed and wished to find a dose which was effective but had a low side effect profile.

Detailed Description

Not available

Study Timeline

• Study Start: 2003-07
• Primary Completion: 2007-01
• Study Completion: 2007-04
• Status Verified: 2008-06
• Study First Submitted: 2008-06-09
• Study First Submitted QC: 2008-06-09
• Last Update Submitted: 2008-06-09
• Study First Posted: 2008-06-11
• Last Update Posted: 2008-06-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• Patients for elective total knee arthroplasty

Exclusion Criteria

• No contraindication to spinal
• No allergy to morphine, rescue analgesia or anti-emesis treatment.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
1	intra thecal morphine	patients in this group got 100mcg of intrathecal morphine.
2	intra thecal morphine	patients in this group got 200 mcg intrathecal morphine
3	intra thecal morphine	patients in this group given 300 mcg intrathecal morphine.

Primary Outcome Measures

Name	Time	Method
pain	24 hours

Secondary Outcome Measures

Name	Time	Method
nausea and vomiting	24 hours
pruritus	24 hours
sedation	24 hours