To know which drug out of the two ( morphine and burprenorphine) used for spinal anesthesia has better pain relief in patients after surgeries of below the umblicus

Not yet recruiting

• Conditions: Central pain syndrome,

• Registration Number: CTRI/2019/02/017811
• Lead Sponsor: Sri Ramakrishna hospital

Brief Summary

Postoperative analgesia is generally the domain of the anaesthesiologist.Intrathecal morphing has been considered as the most effective opioid because of its potency and prolonged duration of action.Buprenorphine intrathecally also provides good postoperative pain relief without prolonging motor or sensory blockade. Hence, this study is designed to compare the effects of Buprenorphine and Morphine as adjuvants to Bupivacaine spinal anesthesia  in patients undergoing infraumblical surgeries. This is a prospective study involving 30 patients in each group. Group B will receive 2.8ml of 0.5% hyperbaric bupivacaine with Buprenorphine 60mcg while, Group M will receive 2.8 ml of 0.5% hyperbaric bupivacaine with 100 mcg of Morphine. Time to first rescue analgesia is the primary objective and secondary objectives include time taken to acheive maximum sensory and motor blockade, vital parameters, adverse effects perioperatively.

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2019-02-14
• Study Start: 2019-11-03

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

ASA Physical status 1 or 2 Presenting for infraumblical surgeries Patients who provide consent for the study.

Exclusion Criteria

Patient allergic to the drug ASA Physical status 3 and above , acute or chronic respiratory disease, cognitive or psychiatric disturbances Any contraindication to subarachnoid block Pregnant women Day care procedures Patients who do not give consent.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To compare the duration of postoperative analgesia of buprenorphine and morphine when given intrathecally with hyperbaric bupivacaine	2, 4, 8, 12, 24 hours of postoperative analgesia

Secondary Outcome Measures

Name	Time	Method
Time taken to achieve maximum sensory and motor block	Intraoperative hemodynamic changes like bradycardia and hypotension and intraoperative side effects like nausea, vomiting and pruritis

Trial Locations

Locations (1)

Sri Ramakrishna hospital; 🇮🇳 Coimbatore, TAMIL NADU, India

Sri Ramakrishna hospital

🇮🇳Coimbatore, TAMIL NADU, India

Dr Hemamalini Arun

Principal investigator

9789875443

dr.s.hemamalini@gmail.com