Role of antibiotic in preventing infections in patients with Child A cirrhosis presenting with gastrointestinal bleeding: A randomized controlled trial
Not Applicable
- Conditions
- Health Condition 1: K74- Fibrosis and cirrhosis of liver
- Registration Number
- CTRI/2021/06/033939
- Lead Sponsor
- I
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
All patients of Child-A cirrhosis presenting with Acute variceal bleed.
Exclusion Criteria
1)Child-B/C cirrhosis
2)Child-A cirrhosis who have received antibiotics prior to randomisation
3)Child-A cirrhosis who have evidence of infection at presentation
4)Child- A cirrhosis with concomitant hepatocellular carcinoma (HCC)
5)Patients with overt hepatic encephalopathy at presentation
6)AVB in patients with ACLF
7)Patients with renal dysfunction at presentation (serum creatinine >1.5g/dl)
8)Pregnant and lactating females
9)Patients with age <15 years or more than 65 years
10)COVID -19 positive patients.
11)Refusal to give consent.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Comparison of incidence of infections (SBP and non-SBP related) between those receiving and not receiving antibiotic prophylaxisin child A patients presenting with acute variceal bleed during the period of hospitalisation due to AVB.Timepoint: 72 hours
- Secondary Outcome Measures
Name Time Method Comparison of the following outcomes between antibiotic treated and non-treated patients: <br/ ><br>1) 6-week rebleed rate <br/ ><br>2)6-week mortality rate <br/ ><br>3)Incidence of failure to control bleed during the index AVB <br/ ><br>Timepoint: 6 weeks