Management of Pythium Keratitis

Completed

Conditions: Corneal ulcer,

Registration Number: CTRI/2019/08/020741

Lead Sponsor: LV Prasad Eye Institute

Brief Summary: 1. Retrospective analysis of cases with laboratory proven *P. insidiosum* keratitis cases will be done by review of medical and microbiology records and the data will be analyzed for epidemiological and clinical characteristics.

2. Evaluate the efficacy Linezolid 0.2% as a monotherapy in patients with corneal infection by *P. insidiosum* and compare with the combination therapy (topical Linezolid 0.2% and Azithromycin 1%) in a Prospective clinical trial

1.

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: All

Target Recruitment: 86

Inclusion Criteria

1.All cases with microbial keratitis confirmed on smears and/or culture as Pythium by Microbiologist.
2.Size of infiltrate less or equal to 8 mm excluding the tentacles.
3.Had not used previously Azithromycin or linezolid 4.Ready to give consent 5.Consent for regular follow-up 6.More than 18 years.

Exclusion Criteria

1.Mixed infection on smears or cultures 2.Known Allergy to Linezolid or Azithromycin 3.Size of infiltrate > 8 mm 4.Not willing to come for regular follow-up or admission or giving consent.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Ulcer completely resolved on medical therapy or application of tissue adhesive for thinning.	Ulcer completely resolved on medical therapy or application of tissue adhesive for thinning.

Secondary Outcome Measures

Name	Time	Method
Number of patients undergone therapeutic Penetrating keratoplasty (TPK) for worsening of infection.	1 month, 3 months and 6 months

Trial Locations

Locations (1): LV Prasad Eye Institute
🇮🇳
Hyderabad, TELANGANA, India
LV Prasad Eye Institute
🇮🇳Hyderabad, TELANGANA, India
Dr Bhupesh Bagga
Principal investigator
04030612615
bhupesh@lvpei.org