Long-term Benefit in Chronic Hepatitis B Patients After Standard Peginterferon Alfa Therapy
- Registration Number
- NCT03181113
- Lead Sponsor
- Xiamen Amoytop Biotech Co., Ltd.
- Brief Summary
In this cohort study, patients with chronic hepatitis B who prior participated in TB1211IFN study and received at least 39 doses of peginterferon alfa will be enrolled. HBsAg/anti-HBs level, HBeAg/anti-HBe level, Serum HBV DNA load and alanine transaminase level will be test every year from the second year to the fifth year after the ending of peginterferon alfa treatment, and long-term benefit of interferon treatment will be evaluated.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 473
- Understand and sign the informed consent form.
- Participated in NCT01760122 study (TB1211IFN) and has received at least 39 doses of peginterferon.
- Conditions which in the opinion of the investigator should be precluded from the study(e.g., poor compliance).
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description peginterferon alfa 2b Peginterferon Alfa-2B - peginterferon alfa 2a Peginterferon Alfa-2A -
- Primary Outcome Measures
Name Time Method rate of HBeAg seroconversion from the second year to the fifth year
- Secondary Outcome Measures
Name Time Method rate of HBeAg seroconversion from the second year to the fifth year decent degree of HBeAg from the second year to the fifth year rate of alanine aminotransferase normalization from the second year to the fifth year rate of HBeAg loss from the second year to the fifth year decent degree of HBV DNA from the second year to the fifth year rate of HBV DNA undetectable from the second year to the fifth year
Trial Locations
- Locations (28)
Peking University People's Hospital
🇨🇳Beijing, Beijing, China
Second Affiliated Hospital Chongqing Medical University
🇨🇳Chongqing, Chongqing, China
Southwest Hospital
🇨🇳Chongqing, Chongqing, China
Xiamen Hospital of T.C.M
🇨🇳Xiamen, Fujian, China
Beijing University Shenzhen Hospital
🇨🇳Shenzhen, Guangdong, China
Beijing Ditan Hospital Capital Medical University
🇨🇳Beijing, Beijing, China
Beijing Youan Hospital, Capital Medical University
🇨🇳Beijing, Beijing, China
Fuzhou Infectious Disease Hospital
🇨🇳Fuzhou, Fujian, China
The First Affiliated Hospital of Xiamen University
🇨🇳Xiamen, Fujian, China
Henan Provincial People's Hospital
🇨🇳Zhengzhou, Henan, China
Xiangya Hospital, Central-south University
🇨🇳Changsha, Hunan, China
Xiangya Second Hospital, Central-south University
🇨🇳Changsha, Hunan, China
302 Military Hospital
🇨🇳Beijing, Beijing, China
Peking University First Hospital
🇨🇳Beijing, Beijing, China
Guangzhou Eighth People's Hospital
🇨🇳Guangzhou, Guangdong, China
Nanfang Hospital
🇨🇳Guangzhou, Guangdong, China
Third Affiliated Hospital, Hebei Medical University
🇨🇳Shijiazhuang, Hebei, China
Huashan Hospital
🇨🇳Shanghai, Shanghai, China
Shenyang Sixth People's Hospital
🇨🇳Shenyang, Liaoning, China
81 Military Hospital
🇨🇳Nanjing, Jiangsu, China
Ruijing Hospital
🇨🇳Shanghai, Shanghai, China
Jinan Infectious Disease Hospital
🇨🇳Jinan, Shandong, China
First Affiliated Hospital of Nanchang University
🇨🇳Nanchang, Jiangxi, China
Tianjin Third Central Hospital
🇨🇳Tianjin, Tianjin, China
Second Hospital of Nanjing
🇨🇳Nanjing, Jiangsu, China
85 Military Hospital
🇨🇳Shanghai, Shanghai, China
Shanghai Public Health Clinical Center
🇨🇳Shanghai, Shanghai, China
First Affiliated Hospital of Wenzhou Medical College
🇨🇳Wenzhou, Zhejiang, China