Long-term Benefit in Chronic Hepatitis B Patients After Standard Peginterferon Alfa Therapy
- Registration Number
- NCT03181113
- Lead Sponsor
- Xiamen Amoytop Biotech Co., Ltd.
- Brief Summary
In this cohort study, patients with chronic hepatitis B who prior participated in TB1211IFN study and received at least 39 doses of peginterferon alfa will be enrolled. HBsAg/anti-HBs level, HBeAg/anti-HBe level, Serum HBV DNA load and alanine transaminase level will be test every year from the second year to the fifth year after the ending of peginterferon alfa treatment, and long-term benefit of interferon treatment will be evaluated.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 473
- Understand and sign the informed consent form.
- Participated in NCT01760122 study (TB1211IFN) and has received at least 39 doses of peginterferon.
- Conditions which in the opinion of the investigator should be precluded from the study(e.g., poor compliance).
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description peginterferon alfa 2b Peginterferon Alfa-2B - peginterferon alfa 2a Peginterferon Alfa-2A -
- Primary Outcome Measures
Name Time Method rate of HBeAg seroconversion from the second year to the fifth year
- Secondary Outcome Measures
Name Time Method rate of HBeAg seroconversion from the second year to the fifth year decent degree of HBeAg from the second year to the fifth year rate of alanine aminotransferase normalization from the second year to the fifth year rate of HBeAg loss from the second year to the fifth year decent degree of HBV DNA from the second year to the fifth year rate of HBV DNA undetectable from the second year to the fifth year
Trial Locations
- Locations (28)
Peking University People's Hospital
๐จ๐ณBeijing, Beijing, China
Second Affiliated Hospital Chongqing Medical University
๐จ๐ณChongqing, Chongqing, China
Southwest Hospital
๐จ๐ณChongqing, Chongqing, China
Xiamen Hospital of T.C.M
๐จ๐ณXiamen, Fujian, China
Beijing University Shenzhen Hospital
๐จ๐ณShenzhen, Guangdong, China
Beijing Ditan Hospital Capital Medical University
๐จ๐ณBeijing, Beijing, China
Beijing Youan Hospital, Capital Medical University
๐จ๐ณBeijing, Beijing, China
Fuzhou Infectious Disease Hospital
๐จ๐ณFuzhou, Fujian, China
The First Affiliated Hospital of Xiamen University
๐จ๐ณXiamen, Fujian, China
Henan Provincial People's Hospital
๐จ๐ณZhengzhou, Henan, China
Xiangya Hospital, Central-south University
๐จ๐ณChangsha, Hunan, China
Xiangya Second Hospital, Central-south University
๐จ๐ณChangsha, Hunan, China
302 Military Hospital
๐จ๐ณBeijing, Beijing, China
Guangzhou Eighth People's Hospital
๐จ๐ณGuangzhou, Guangdong, China
Nanfang Hospital
๐จ๐ณGuangzhou, Guangdong, China
Third Affiliated Hospital, Hebei Medical University
๐จ๐ณShijiazhuang, Hebei, China
Huashan Hospital
๐จ๐ณShanghai, Shanghai, China
Shenyang Sixth People's Hospital
๐จ๐ณShenyang, Liaoning, China
81 Military Hospital
๐จ๐ณNanjing, Jiangsu, China
Ruijing Hospital
๐จ๐ณShanghai, Shanghai, China
Jinan Infectious Disease Hospital
๐จ๐ณJinan, Shandong, China
First Affiliated Hospital of Nanchang University
๐จ๐ณNanchang, Jiangxi, China
Tianjin Third Central Hospital
๐จ๐ณTianjin, Tianjin, China
Second Hospital of Nanjing
๐จ๐ณNanjing, Jiangsu, China
85 Military Hospital
๐จ๐ณShanghai, Shanghai, China
Shanghai Public Health Clinical Center
๐จ๐ณShanghai, Shanghai, China
First Affiliated Hospital of Wenzhou Medical College
๐จ๐ณWenzhou, Zhejiang, China
Peking University First Hospital
๐จ๐ณBeijing, Beijing, China