Treatment of shwitra w.s.r to vitiligo in children through ayurvedic line of management.

Phase 4

Recruiting

Conditions: Other specified disorders of the skin and subcutaneous tissue. Ayurveda Condition: SVITRAH, (2) ICD-10 Condition: L80||Vitiligo. Ayurveda Condition: SVITRAH,

Registration Number: CTRI/2024/01/061619

Lead Sponsor: Shree jagadguru gavisiddeshwara ayurvedic medical college post graduate studies and research center

Brief Summary: Vitiligo is macular depigmentation of skin associated with destruction of melanocytes

which is typically characterized by non-scaly chalky white macule formation on the skin1

.

The prevalence of vitiligo ranges from 0.06 to 2.28%, whereas this was 0.0â€“2.16%

in children/adolescents populations2

. Males and females are equally affected. This may be

hereditary, medicine originated or side effects of radiation or chemotherapy.

Disease possesses a major cosmetic problem in the affected. The affected people feel

isolated from the society, they feel loss of self-esteem & get depressed psychologically,

especially school going children. Hence this condition has social stigma.

Management of vitiligo includes topical steroids, topical photochemotherapy,

minigrafting and depigmentation techniques. The present mainstay medications for vitiligo

include NB-UVB (Narrow band Ultraviolet B) phototherapy and PUVA (Oral psoralen +

Ultraviolet A) photochemotherapy3

. Of them, the former is the preferred method, which has

the short-term side effects of pruritus, xerosis, and burning, and the latter increases the risk

of skin cancer 4.

In children recurrent or prolonged arrhythmogenic UV exposure in early childhood

increases the likelihood of development of melanoma & non melanoma skin cancer5

The counterpart of Vitiligo in Ayurveda is Shwitra, also called Kilaasa, and Daruna.

It is considered to be resulting from misdeeds (papakarma) of present and past life

predominantly, and improper dietary habits (virodhi annam).6

It is one among the raktha

pradoshaja vikaras7

.

It is characterized by swetha mandala. It can be correlated to vitiligo in certain extent.

According to Ayurveda Vata & Bhrajaka pitta resides in skin. Any imbalance in Vata &

Bhrajaka pitta may causes skin diseases. As skin covers all over the body, Bhrajaka pitta

should be maintained in proper state.

Since the nidanas and lakshanas mentioned for Shwitra are not clinically sufficient,

it also opens up the space for different research on various aspects of etiopathology and

clinical manifestations of Shwitra. Description regarding stage-wise treatment of Shwitra

has been explained in the Ayurvedic classics.

Lepa, shodhana, raktha mokshana, rukshana and sakthu bhakshana are the

treatments8-9

explained for Shwitra in Ayurveda. In day-to-day practice physicians facing

lots of difficulties in doing shodhana procedures in children so focus has been made on LEPA chikitsa. Various Lepas Mentioned in Ayurveda, few of lepas have been proved their

repigmentation effect over shwitra by past Researches & Among them Navaneetakadi lepa

is mentioned as said to be cures shwitra within 7 days in the context of shwitra in Aarogya

Raksha Kalpa Dhrumah

10

.

Navaneetakadi lepa-This yoga is cost effective and can be prepared & applied

easily, so in this present study, repigmentation effects of Navaneetakadi lepa is compared

with the standard Avalgujadi lepa

11 in Management of Shwitra has been taken.

Detailed Description: Not available

Recruitment & Eligibility

Status: Open to Recruitment

Sex: All

Target Recruitment: 40

Inclusion Criteria

Children diagnosed with sadhya lakshana15 of Shwitra & Age group of 2-16 years irrespective of gender, religion, occupation and children of parents who are allowing their children to participate in the study after taking consent from parents will be included.

Exclusion Criteria

Children with Shwitra diagnosed with asadhya lakshana15 like Shwitra presenting over the genital areas, inner part of lips, palms & associated with depigmented hairs will be excluded.
Vitiligo associated with burnt areas, psoriasis, albinism or other skin diseases and any other systemic diseases and autoimmune disorders will be excluded.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Repigmentation of skin in shwitra(vitiligo)	28 days

Secondary Outcome Measures

Name	Time	Method

Trial Locations

Locations (1): Shree jagadguru gavisiddeshwara ayurvedic medical college post graduate studies and research center
🇮🇳
Koppal, KARNATAKA, India
Shree jagadguru gavisiddeshwara ayurvedic medical college post graduate studies and research center
🇮🇳Koppal, KARNATAKA, India
Dr Dipak P Dhangar
Principal investigator
7020450128
drdipakdh321@gmail.com