Is antibiotic treatment associated with reduced risk of a subsequent exacerbation and mortality in chronic obstructive lung disease? A randomized clinical trial.
Completed
- Conditions
- COPD, antibiotics, exacerbation, doxycyclinCOPD, antibiotica, exacerbatie, doxycycline
- Registration Number
- NL-OMON28324
- Lead Sponsor
- Academic Medical Center, Amsterdam
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 470
Inclusion Criteria
1. Age 45 years and older;
2. COPD GOLD 1, 2 or 3;
Exclusion Criteria
1. Poor cognitive functioning;
2. Poor mastering of the Dutch language;
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Time to next exacerbation.
- Secondary Outcome Measures
Name Time Method 1. Mortality during follow up;<br /><br>2. Number of exacerbations during follow up;<br /><br>3. Treatment failure rate at test of cure (day 21) and late follow-up (day 90);<br /><br>4. Cultured microorganisms at subsequent exacerbation, and, in subgroup, during 6 months after exacerbation;<br /><br>5. Health related quality of life;<br /><br>6. Decline of lung volumes;<br /><br>7. Total antibiotic use;<br /><br>8. Costs.