Acylcarnitine Profile After Intensive Care

Recruiting

• Conditions: Critical Care; Carnitine Metabolism Disturbances
• Interventions: Diagnostic Test: Serum acylcarnitine profiling

• Registration Number: NCT05115734
• Lead Sponsor: University of Liege

Brief Summary

The aim of the study is to compare the acylcarnitine profile of critically ill survivors of a prolonged stay in ICU with the profile of survivors of short ICU length of stay. The second aim is to assess the evolution of the acylcarnitine profile over time in survivors of a prolonged ICU stay.

Detailed Description

In a retrospective analysis focused on survivors of an ICU stay of 7 days or more, we showed that during the week following discharge, carnitine deficiency was rare, but acylcarnitine profile was altered, with an abnormal acylcarnitine/carnitine ratio in more than 25% of the population.

Carnitine has a key role in cellular energy metabolism and is a a biomarker of the mitochondria function. Moreover, mitochondrial function is proven to be severely impaired in critically ill patients and mitochondrial dysfunction has been linked to post-ICU disorders.

In this context, it is relevant to study the evolution over time of the acylcarnitine profile in ICU survivors of a prolonged ICU stay. It is also relevant to compare the same profile between survivors of a prolonged and a shorter ICU stay.

Study Timeline

• Study First Submitted: 2021-10-30
• Study First Submitted QC: 2021-10-30
• Study Start: 2021-11-03
• Study First Posted: 2021-11-10
• Status Verified: 2023-06
• Last Update Submitted: 2023-06-25
• Last Update Posted: 2023-06-27
• Primary Completion: 2025-01-01
• Study Completion: 2026-01-01

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• Group short stayers: ICU length of stay of 2 days
• Group long stayers: ICU length of stay of at least 7 days

Exclusion criteria: patient refusal

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Short stayers	Serum acylcarnitine profiling	Determination of the acylcarnitine profile during the 5 days following discharge of a short stay in ICU (maximum 2 days)
Long stayers	Serum acylcarnitine profiling	Determination of the acylcarnitine profile during the year following discharge of a prolonged stay in ICU (7 days or more)

Primary Outcome Measures

Name	Time	Method
Acylcarnitine profile	12 month following ICU discharge	Serum acylcarnitine profile in long stayers

Trial Locations

Locations (1)

University Hospital of Liège; 🇧🇪 Liège, Belgium