High dose folic acid supplementation effect on preeclampsia
- Conditions
- Preeclampsia.Gestational [pregnancy-induced] hypertension with significant proteinuria
- Registration Number
- IRCT201507313944N4
- Lead Sponsor
- Isfahan University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- Female
- Target Recruitment
- 900
all of women with living fetus in the uterine cavity in first trimester with willingness for participation in this study, were included and do not: Presence or history of a disorder in which administration of folic acid is contraindicated, renal diseases, using anti-epileptic drugs (since the metabolism of anti-epileptic drugs requires a great deal of folic acid), malignancy, alcohol abuse, multiple birth (presence of three living fetus or more) and known hypersensitivity to folic acid (rashes, dermatologic and gastroenterological discomforts).
Exclusion criteria: Fetal death during the study, major abnormality of the fetus, women who were planning to move outside of the catchment area of the study within the pregnancy duration.
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Preeclampsia. Timepoint: first visit and routin prenatal care. Method of measurement: measurement blod pressure (mmHg) and proteinuria(mg/dl).
- Secondary Outcome Measures
Name Time Method Incidence of preeclampsia. Timepoint: during pregnancy. Method of measurement: using diagnostic criteria.;Severity of preeclampsia. Timepoint: during pregnancy. Method of measurement: using diagnostic criteria.;Prevalence of preeclampsia. Timepoint: during pregnancy. Method of measurement: using diagnostic criteria.