Effects of Different Polyphenol-containing Beverages on the Immune System and on Muscular Growth Factors

Not Applicable

Completed

• Conditions: Food Sensitivity
• Interventions: Other: non-alcoholic wheat beer; Other: non-alcoholic Pilsner; Other: lemonade; Other: apple spritzer

• Registration Number: NCT04983420
• Lead Sponsor: Balgrist University Hospital

Brief Summary

In this research project, the effect of different polyphenol-containing beverages with varying alcohol content of \< 0.4 vol% on immune function as well as muscular growth factors will be investigated

Detailed Description

Not available

Study Timeline

• Study Start: 2021-01-01
• Study First Submitted: 2021-05-06
• Study First Submitted QC: 2021-07-20
• Study First Posted: 2021-07-30
• Primary Completion: 2021-09-30
• Study Completion: 2023-05-31
• Status Verified: 2023-08
• Last Update Submitted: 2023-08-14
• Last Update Posted: 2023-08-15

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• Healthy
• Age 20 - 60 years
• Written informed consent

Exclusion Criteria

• severe gastrointestinal disease or known malabsorption
• use of proton pump inhibitors
• malignancies
• rheumatoid diseases
• metabolic syndrome
• acute or chronic infections or inflammatory diseases
• use of medications or supplements to interfere with immune function
• alcohol and/or drug abuse or addiction
• dependent relationship with the project manager or his or her employees
• pregnancy or breastfeeding
• chronic illness or regular use of medication (except hormonal contraception)
• smoker

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
non-alcoholic wheat beer	non-alcoholic wheat beer	1 L non-alcoholic wheat beer per day for 2 weeks
non-alcoholic Pilsner	non-alcoholic Pilsner	1 L non-alcoholic Pilsner per day for 2 weeks
lemonade	lemonade	1 L lemonade per day for 2 weeks
apple spritzer	apple spritzer	1 L apple spritzer per day for 2 weeks

Primary Outcome Measures

Name	Time	Method
white blood cells	after 14 days of daily intake	white blood cell count
inflammatory markers in the blood	after 14 days of daily intake	IL-6, TNF- α, hs-CRP
polyphenol in the urine	after 14 days of daily intake	polyphenol level in the urine
blood alcohol	after 14 days of daily intake	blood alcohol level

Secondary Outcome Measures

Name	Time	Method
physical activity	day 14 of beverage intake	Global Physical Activity Questionnaire (allows to calculate metabolic equivalents to express the intensity of physical activities
dietary habit	day 12-14 of beverage intake	3 day food diary

Trial Locations

Locations (1)

Balgrist University Hospital; 🇨🇭 Zurich, Switzerland