octurnal Dexmedetomidine for prevention of delirium in high risk patients admitted to ICU after non-cardiac surgery: a Randomised, Double-Blind, Placebo-Controlled Trial

Faculty of Medicine Siriraj Hospital, Mahidol University0 个研究点目标入组 114 人开始时间: 2021年2月17日最近更新: 2024年8月19日

适应症

试验速览

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•1.Age 18 years or older undergoing non-cardiac surgery
•2.Admitted to SICU immediately after surgery (before 6 PM on the day of surgery)
•3.A predictive score of postoperative delirium of 115 or more
•4.Expected to stay in SICU for more than 24 hours

•1.Unable to communicate in Thai
•2.Preoperative history of schizophrenia, epilepsy, Parkinsonism, myasthenia gravis
•3.Inability to communicate in the preoperative period (coma, profound dementia, or language barrier)
•4.Admitted with a primary neurologic condition or injury
•5.Known preoperative LVEF less than 30%
•6.Sick sinus syndrome, severe sinus bradycardia (<50 beats per min [bpm]), or second-degree or greater atrioventricular block without pacemaker
•7.Child-Pugh class C
•8.Serious renal dysfunction (undergoing dialysis before surgery)
•9.Known allergies or anaphylaxis of dexmedetomidine, propofol, midazolam, haloperidol
•10.Expected death within 48 hours after surgery
•11.Inability to obtain informed consent
•12.Pregnancy

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