PRomoting early diagnosis Of chronic Mesenteric ISchEmia by a mesenteric artery calcium score based risk stratification and detection of postprandial mucosal ischemia by butyrate breath testing

Recruiting

Conditions: Chronic mesenteric ischemia
intestinal oxygen shortage
10018031

Registration Number: NL-OMON53338

Lead Sponsor: Erasmus MC, Universitair Medisch Centrum Rotterdam

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 296

Inclusion Criteria

- - Patients with a clinical suspicion of CMI referred to Maagdarm Ischemie
Centrum Rotterdam (MICR), Medical Spectrum Twente (MST) or UMC Groningen
- Patients >= 18 years

Exclusion Criteria

- Patients who are unable to give informed consent
- Patients with previous mesenteric artery revascularization
- No available CT imaging and contraindications for CT imaging (e.g. pregnancy)
- Common origin of the celiac artery and superior mesenteric artery
- Known delayed gastric emptying
- Known and untreated small intestinal bacterial overgrowth

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>1) MACS: An existing abdominal CT is used to calculate the MACS of the celiac<br /><br>artery and superior mesenteric artery.<br /><br>2) Butyrate breath testing: Patients will receive 13C-butyrate dissolved in a<br /><br>high caloric drink (Nutridrink). Multiple test tubes filled with expired air of<br /><br>13CO2 will be collected during a period of 2 hours.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- To determine cut of values for the MACS with high specificity and high<br />negative predictive value.<br />- To validate the symptom and CT based MACS score chart for early risk<br />stratification of patients with suspected CMI. </p>