Flat colorectal cancer precursor lesions: epidemiological aspects and molecular analysis.
Recruiting
- Conditions
- colorectal cancer, precursor lesions, adenoma, flat, non-polypoid, high-risk population, family history of colorectal cancer
- Registration Number
- NL-OMON28777
- Lead Sponsor
- Maastricht University Medical Center, department of gastroenterology and hepatology
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 2500
Inclusion Criteria
Patients referred for routine colonoscopy with or without positive familiy history for colorectal cancer.
Exclusion Criteria
Molecular analysis: patients with inflammatory bowel disease.
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. Prevalence of flat colorectal lesions in a Dutch population;<br /> <br>2. Clinical characteristics (e.g. location of lesions, percentage of high-grade dysplasia or early cancer);<br /> <br>3. Molecular charcteristics (epigenetic: methylation status and genetic) of flat vs. polypoid colorectal lesions;<br /> <br>4. Prevalence of flat advanced colorectal cancers vs. polypoid advanced colorecal cancers: clinical features of these lesions (e.g. tumor stage);<br /> <br>5. Relation between serrated and adenomatous polyps. <br>
- Secondary Outcome Measures
Name Time Method Prevalence and genotype and fenotype associations of flat colorectal lesions in patients at high-risk for colorectal cancer.