The Effectiveness of BreatheMAX Breathing Device on Airway Secretion Clearance in Patients With Ventilatory Dependence
试验速览
- 阶段
- 2 期
- 入组人数
- 14
- 试验地点
- 2
- 主要终点
- secretion wet weight (gram)
研究概览
简要总结
The purpose of this study is to determined effects of BreatheMAX on secretion clearance.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Double (Participant, Care Provider)
入排标准
- 年龄范围
- 15 Years 至 85 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •One sign of secretion accumulation in bronchi
- •Stable cardiopulmonary function
- •Good consciousness and good co-operation
排除标准
- •Massive hemoptysis
- •Pneumothorax (untreated)
结局指标
主要结局
secretion wet weight (gram)
时间窗: Three hours before, ten hours after treatment and night-time (02.00-07.00 am.)
Airway mucus secretion was collected for three hours before and ten hours after treatment based on an auditory airway secretion sound and collected again at 02.00-07.00 am.The mucus secretion was collected by sterile suctioning technique via tracheostomy tube without adding any saline or sterile water.
viscosity of secretion
时间窗: Three hours before and after treatment
The secretion were collected in three hours before and after treatment, It were measured viscosity by First The mucus was gently homogenized by tissue grinder 5 ml (Cw11-205, Cowie, UK) for six minute at 37 degree celsius Second using Micro-Oswald viscometers with a capillary diameter of 0.77 mm for viscosity measure at same temperature in each sample(before and after).
次要结局
- Oxygen saturation (%SpO2)(Before, during breathing exercise with device and immediate after treatment)
- Heart rate (beat/min)(Before, during breathing exercise with device and immediate after treatment)
- Respiratory rate (times/min)(In rest interval between set (1 minute))